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CD19 Molecule Synonym Name


CD19 Protein Products

Cat No Species Product Description
CD9-C5251 Rhesus macaque Rhesus macaque CD19 (20-292) Protein, Fc Tag
CD9-H5255 Human Human CD19 (20-278) Protein, Fc Tag
CD9-H5259 Human Human CD19 (20-291) Protein, Fc Tag
CD9-H8259 Human Biotinylated Human CD19, Fc Tag, ultra sensitivity (primary amine labeling)
CD9-H52H2 Human Human CD19 (20-291) Protein, His Tag

CD19 Molecule Background

B-lymphocyte antigen CD19 (CD19) is also known as B-lymphocyte surface antigen B4, Differentiation antigen CD19 and T-cell surface antigen Leu-12, which is a single-pass type I? membrane protein and contains two?Ig-like C2-type (immunoglobulin-like) domains. CD19 forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. CD19 interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. CD19 also interacts with PLCG2 when phosphorylated on Tyr-409. CD19 is an important pan B cell marker and co-stimulatory protein in humans and mice. CD19 is a hallmark differentiation antigen of the B cell lineage and positively regulates antigen receptor signal transduction in mature B cells. CD19 defines signaling thresholds for the Ag receptor as well as other cell surface receptors that regulate B lymphocyte selection, activation, and differentiation. Defects in CD19 are a cause of hypogammaglobulinemia.





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