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Your Position: Home > COVID-19 R&D > Where do we go from here: A reflection of COVID-19
Where do we go from here: A reflection of COVID-19
Release time: 2021-09-10 Source: ACROBiosystems Read: 6563

In Jan 2020, the sudden emergence of a previously unknown, highly contagious respiratory pathogen launched a global pandemic that remains circulating today. The SARS-CoV-2 coronavirus that causes COVID-19 has surpassed 211 million infections worldwide within twenty months of the pandemic, resulting in more than four million deaths until August 2021 (Coronavirus Resource Center, 2021). Not since 1918 has the world been so affected by the emergence, spread, and death toll resulting from a respiratory virus that impacted on not only global public health but also the economic status of nations and individuals. This devastating public health emergency called for a comprehensive response that required the joint effort of pharmaceutical, biotech, and academic collaborators to develop prevention and treatment approaches for this new disease.

This article is a reflection of COVID-19, following some possible solutions for related research, vaccine and diagnostics development.

• What we have achieved in the fight against COVID-19

• What remains unknown about the virus

• What ACRO offer

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ACROBiosystems is dedicated to aid the global COVID-19 response. As a leading life science supplier, we remain steadfast in our mission to support researchers, developers and manufacturers with key reagents to better address the persisting public health concerns. As such, we have consolidated our product and service offerings to a comprehensive solution for SARS-CoV-2, which meet customers' need in both the detection of COVID-19 and the development of vaccines and therapies. As SARS-CoV-2 continues to spread and evolve, our top priority is to provide support to rapidly respond to the challenges. Now, more than ever, we are mobilizing forces to keep the circulating and emerging SARS-CoV-2 variants under surveillance and develop products targeting the Variants of Concerns (VOCs) in the timeliest manner. Our product pipeline includes multiple recombinant antigen mutants, broadly neutralizing antibodies, ELISA kits with high sensitivity and protein-pre-coupled magnetic beads that support high-throughput applications.

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Recombinant antigens
We provide a collection of recombinant antigen proteins of all VOCs and other prevalent SARS-CoV-2 variants, covering critical mutations such as K417N/T, L452R/Q, E484K, N501Y and D614G on the spike protein; and R203G, G204R on the nucleocapsid protein, etc
Different antigens are provided, i.e., Spike RBD, Spike Trimer, S1, S2, Spike NTD and Nucleocapsid protein
The antigen mutants have verified high purity, high bioactivity and high stability.
Products with multiple tags (His, Avi, Fc, mFc) are available in bulk supply.

>>> Featured products: Super stable spike trimer

① 6P and 2A mutations were introduced to stabilize the trimeric protein in its pre-fusion configuration and abolish the S1/S2 furin-cleavage site, respectively

② Cover mutations reported on Alpha / Beta / Gamma / Delta variants (VOCs)

③ Developed based on the updated sequence information retrieved from GISAID / PANGOLIN / Nextstrain database

④ High trimer purity (>90%) verified by SEC-MALS

⑤ Suitable for inhibitor screening assays and serological antibody titer tests

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Recombinant antigens
We have selected a collection of neutralizing antibodies, binding antibodies, antibodies for diagnostic, IgG antibody isotype and HRP-secondary antibody etc. against the variants.
High purity, high bioactivity and high stability with verification
Facilitate the development of serologic tests, therapeutic antibodies and vaccines
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>>> Featured products: Broad-spectrum neutralizing antibody (Cat.No. S1N-M122)

① Can potently neutralize all the VOCs in pseudovirus neutralization assay

② Suitable to be a positive control in inhibitor screening tests

>>> Featured products: Anti-nucleocapsid antibody pair (Cat.No. NUN-M223/NUN-S95)

① Can recognize all the prevalent nucleocapsid protein variants verified by colloidal gold-based assay

② An ideal ingredient for development of antigen detection tools.

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Recombinant antigens
We have developed a series of ELISA kits for SARS-CoV-2 detection, including antibody serological titer kits, neutralizing antibody serological titer kits, antigen titer kits, variants inhibitor screening kits, antigen-pre-coated plates, etc.
High sensitivity and specificity.
Can significantly increase your experiment efficiency while ensuring highly reproducible results.
High-throughput, can test 90+ samples in two hours
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>>> Featured products: VOCs-specific neutralizing antibody serological titer kits

LineageCat. No.
SARS-CoV-2  (U.K) Alpha | B.1.1.7RAS-N028
SARS-CoV-2  (South Africa) Beta | B.1.351RAS-N031
SARS-CoV-2  (Brazil) Gamma | P.1

RAS-N034
SARS-CoV-2  (India) Delta | B.1.617.2

RAS-N040 , RAS-N041

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Pre-coupled Magnetic Beads
Produced by coupling biotinylated antigens to streptavidin-conjugated magnetic beads
Pre-coupled & ready to use for capturing target proteins from the sample
Can be used for capturing anti-SARS-CoV-2 antibody or ACE2 protein from your sample with high specificity
High yield and low non-specific binding
Suitable for immunocapture, biopanning, flow cytometry, etc.
Cost effective: cut time and human effort during experiment
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>>> Featured products: VOCs-specific neutralizing antibody serological titer kits

Cat.No.Product DescriptionApplicationPreorder/Order
MBS-K001SARS-CoV-2 Spike S1-coupled Magnetic BeadsS1 protein antibody screening

Order

MBS-K002SARS-CoV-2 Spike RBD-coupled Magnetic BeadsSpike protein RBD antibody screening

Order

MBS-K013Human ACE2-coupled Magnetic BeadsVirus capture

Order

MBS-K014Human Anti-SARS-CoV-2 Spike RBD Antibody-coupled Magnetic BeadsVirus capture

Order

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>>> References

[1] COVID-19 Map, Johns Hopkins Coronavirus Resource Center, 27 Aug 2021. Retrieved from https://coronavirus.jhu.edu  /map.html

[2] WHO Coronavirus (COVID-19) Dashboard with Vaccination Data, World Health Organization, 27 Aug 2021. Retrieved from   https://covid19.who.int/

[3] 7 Vaccines Approved for Use by WHO, COVID-19 Vaccine Tracker. Retrieved from https://covid19.trackvaccines.org  /agency/who/

[4] Scudellari M. How the coronavirus infects cells — and why Delta is so dangerous. Nature (28 July 2021). Retrieved from   https://www.nature.com/articles/d41586-021-02039-y

[5] Andersen, K.G., Rambaut, A., Lipkin, W.I. et al. The proximal origin of SARS-CoV-2. Nat Med 26, 450‒452 (2020).   https://doi.org/10.1038/s41591-020-0820-9

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