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Your Position: Home > R-Spondin-1 / RSPO1 Molecule

R-Spondin 1 Molecule Synonym Name


R-Spondin 1 Protein Products

Cat No Species Product Description
RS1-H4221 Human Human R-Spondin 1 / RSPO1 Protein
RS6-H4220 Human Human R-Spondin 1 / RSPO1 (21-146) Protein

R-Spondin 1 Molecule Background

R-spondin-1 is also known as Roof plate-specific Spondin 1 (RSPO1) and cysteinerich and single thrombospondin domain containing protein 3 (Cristin 3), which is a secreted protein which belongs to the R-Spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. All Rspondins regulate Wnt/β-catenin signaling, but have distinct expression patterns. Like other R-Spondins, R-Spondin-1 contains two adjacent cysteinerich furinlike domains (aa 34-135) with one potential N-glycosylation site, followed by a thrombospondin (TSP1) motif (aa 147-207) and a region rich in basic residues (aa 211-263). Only the furinlike domains are needed for β-catenin stabilization. A putative nuclear localization signal at the C-terminus may allow some expression in the nucleus.


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