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Your Position: Home > Discovery Solutions for Cell and Gene Therapy

Discovery Solutions for Cell and Gene Therapy

Discovery Solutions for Cell and Gene Therapy
Background
The pipeline of advanced therapy is expanding at a rate never seen before, with a number of cell and gene therapies (CGT) now reaching the market. Continuing advances in CGT are transforming how biopharma companies treat and potentially cure certain diseases.
Cell and gene therapies are the next wave of therapeutic innovation in the life sciences industry. However, the consequent challenges in development, manufacture, quality control, supply chain and commercial affect the whole industry.
As a leading manufacturer of recombinant proteins and other critical reagents to support the development of biomedicine, ACROBiosystems is proud to stand by you in the CGT journey. We employ an application-oriented development strategy, with a particular focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey. Our products and services enable anyone in the field of drug development to have a more intuitive and streamlined process.
CGT solutions
           
           

Early drug discovery

Suitable for immunization, antibody screening and antibody affinity testing
More than 50 targets for solid tumor and blood tumor
PE/FITC/Biotin/Unconjugated labeled proteins are available
Some products have completed the FDA DMF filing (DMF No.: 034936), which can support your IND, NDA, and BLA.
>>>Find out more
             
Suitable for TCR testing and screening
Monomer and tetramer are available for different applications
High purity verified by SDS-PAGE; High affinity verified by SPR
High stability and batch-to-batch consistency
>>>Find out more
Suitable for structure design and gene edition
High enzyme activity: improve the cutting efficiency to 90% and make it easier to edit gene by CRISPR
High purity verified by SDS-PAGE(>90%)and SEC-MALS(>95%)
Bioactivity verified by in-vivo/ in-vitro assay: gene knockout activity in vivo and fragment cleavage activity in vitro
Low endotoxin less than 0.1 EU/ug
High stability and batch-to-batch consistency
RUO grade products can save the cost in early study; GMP grade products are coming
>>>Find out more

Manufacture/Quality control

Suitable for cell culture and expansion
(research use and ex vivo cell culture processing only, and is not intended for human in vivo applications)
Strict Quality Control Standards: 16 quality control standards and Excellent safety profile. High stability and batch-to-batch consistency.
GMP Grade Quality Management System: ISO 5 cleanrooms used for filling, raw materials and packing materials are registered, and facilities are available for online and on-site audits.
Accelerating Global Regulatory Approval of Biological Products: A comprehensive set of regulatory documents and validation reports are available by request. FDA DMF filing in progress.
>>>Find out more
             
Suitable for nucleic acid removing in Lentivirus purification process and AAV preparation process
High purity verified by SDS-PAGE and HPLC(> 95%), high specific activity > 1.0 x 106 unit/mg
Tag Free and close to the natural state, performs a high enzyme activity≥250 U/μl
No protease activity, high specificity and sensitivity
Broader reaction conditions: Optimum temperature 35 °C -42 °C, optimum pH 8.0 - 8.5
Some products have completed the FDA DMF filing (DMF No.: 034936), which can support your IND, NDA, and BLA.
RUO grade products can save the cost in early study; GMP grade products are coming
>>>Find out more

Recommended for human T cell activation & expansion
Microbial testing and ultra-low endotoxin (<2 EU/mg)
Efficient activation and expansion
High batch-to-batch consistency
Highly stable and convenient for storage and transportation in lyophilization
RUO grade products can save the cost in early study; GMP grade products are coming
>>>Find out more

One-step solution for CAR detection with higher specificity and less processing time, no secondary antibody and non-specific background
More fluoresces are available: FITC/PE/APC, etc.
More advanced technology: use new-generation site-specific labeling technology to maintain natural conformation and modification of the proteins
More stringent quality control standard: High sensitivity and specificity verified by FACS, no non-specific binding to non-transduced PBMCs, high batch-to-batch consistency and stability that meet the requirements of clinical sample analysis
Recommended: More pre-labeled proteins for different applications
>>>Find out more

Suitable for the quantitative of cytokine in serum and cell matrix(RUO)

Self-development based on ACRO’s protein production platform, performance and supply ability and quality assured
High sensitivity, specificity and accuracy, strict method validation and quality control to ensure the within-run and between-run precision
Easy to use and high through put, at most 82 samples can be tested at one time in 2 hours
Customized service and antibodies materials are available Inquiry
>>>Find out more

Non-clinical studies/Clinical research

Pharmacokinetics (PK) research
Suitable for detecting CAR expression by flow cytometry in preclinical and clinical samples
More than 50 targets for solid tumor and blood tumor
PE/FITC/Biotin labeled proteins are available
High stability and batch-to-batch consistency, performs well in flow cytometry in clinical trials
No non-specific binding to non-transduced PBMCs
Some products have completed the FDA DMF filing (DMF No.: 034936), which can support your IND, NDA, and BLA.
>>>Find out more
             
Suitable for detecting TCR by flow cytometry in preclinical and clinical trials
Monomer and tetramer are available for different application
High purity verified by SDS-PAGE; High affinity verified by SPR
High stability and batch-to-batch consistency
>>>Find out more
Suitable for CAR expression by flow cytometry in preclinical and clinical samples
Featured anti-FMC63 antibody can specifically recognize the antigen-binding site of FMC63 derived CARs with high affinity
Suitable for detecting FMC63 derived anti-CD19 CARs in clinical trials
Overcome the challenges for complex cell components, low CAR-T cell concentration and non-specific background, etc.
Fluorescent-labeled products are available for one-step detection, reducing process time
Recommended: FM3-HPY53, FM3-FY45, FM3-BY54
>>>Find out more
>>>Anti-Idiotypic Antibody Development Service
Immunogenicity evaluation
Suitable for detecting and characteristic of anti-drug antibodies
Monoclonal anti-idiotype antibody, polyclonal anti-idiotype antibody are available
Neutralizing antibodies, suitable for various ADA assay development(Direct/In-direct/Bridge ELISA,RIPA,SPR,Cell-based assay,Competitive Ligand Binding Assay)
Recommended products:FM3-S93, FM3-Y45A1
>>>Find out more
             
ACRO provides cell therapy researchers with one-stop services from antigen preparation to polyclonal anti-idiotype antibody and immunogenicity test kit developments.>>>Find out more

           
Pharmacodynamic and safety studies
Suitable for the quantitative of cytokine in serum and cell matrix(RUO)
Self-development based on ACRO’s protein production platform, performance and supply ability and quality assured
High sensitivity, specificity and accuracy, strict method validation and quality control to ensure the within-run and between-run precision
Easy to use and high through put, more than 82 samples can be tested at one time in 2 hrs
Customized service and antibodies materials are availableInquiry
>>>Find out more
             
PRODUCT LIST
  • GMP Grade Cytokines

  • Fluorescent-labeled Products

  • Targets for Cell Therapy

  • Anti-idiotypic Antibodies

  • Magnetic Beads

  • Nucleases

  • Cytokine ELISA Kits

MoleculeCat.No.Product descriptionPreorder/Order
IL-15GMP-L15H13GMP Human IL-15

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IL-7GMP-L07H24GMP Human IL-7

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IL-21GMP-L21H25GMP Human IL-21

Preorder

MoleculeCat. No.Product DescriptionPreorder/Order
BCMABCA-HF2H3FITC-Labeled Human BCMA / TNFRSF17 Protein, His Tag Star Staining

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CD19CD9-HF2H3FITC-Labeled Human CD19 (20-291) Protein, His Tag Star Staining

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MesothelinMSN-HF2H3FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag Star Staining

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Siglec-2SI2-HF2H4FITC-Labeled Human Siglec-2 / CD22 Protein, His Tag Star Staining

Preorder

FMC63FM3-FY57P1FITC-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) Star Staining

Preorder

CD19CD9-HP2H5PE-Labeled Human CD19 (20-291) Protein, His Tag Star Staining

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BCMABCA-HP2H7PE-Labeled Human BCMA / TNFRSF17 Protein, His Tag Star Staining

Preorder

MesothelinMSN-HP2H8PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag Star Staining

Preorder

CD19CD9-HA2H9APC-Labeled Human CD19 (20-291) Protein, His Tag Star Staining

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BCMABCA-HA2H4APC-Labeled Human BCMA / TNFRSF17 Protein, His Tag Star Staining

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MesothelinMSN-HA2H6APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag Star Staining

Preorder

Cat. No.SpeciesProduct DescriptionApplicationPreorder/Order
FM3-Y45MouseMonoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) DMF FiledCAR expression by flow cytometry in preclinical and clinical samples

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FM3-FY45MouseFITC-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) DMF Filed

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FM3-BY45MouseBiotinylated Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) DMF Filed

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FM3-Y45P1MouseMonoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (HEK293) DMF Filed

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FM3-HPY53MousePE-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (Site-specific conjugation) DMF Filed

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FM3-BY54MouseBiotinylated Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1, Avitag™ (Y45) DMF Filed

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FM3-FY45P1MouseFITC-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (HEK293)

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FM3-Y45A1MouseMonoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (Carrier-free) (recommended for ADA assay) DMF FiledADA assay development

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FM3-S93RabbitRabbit Anti-Mouse FMC63 scFv Polyclonal Antibody (recommended for ADA assay) (MALS verified)

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Cat. No.Product DescriptionApplicationPreorder/Order
MBS-C001Anti-CD3/CD28 Antibody-coupled Magnetic BeadsCell activation and expansion

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MoleculeCat. No.Product DescriptionPreorder/Order
Cas9CA9-S5149NLS-Cas9 Nuclease

Preorder

Cas12aCAA-L5149NLS-Cas12a Nuclease

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BenzNucleaseBEE-N3116GENIUS™Nuclease DMF Filed

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MoleculeCat. No.Product DescriptionPreorder/Order
IFN-γCRS-A001Human Interferon-γ(IFN-γ) ELISA Kit

Preorder

TNF-αCRS-A002Human Tumor Necrosis Factor Alpha(TNF-α) ELISA Kit coming soon

Inquiry

IL-2CRS-A003Human Interleukin-2(IL-2) ELISA Kit coming soon

Inquiry

IL-4CRS-A004Human Interleukin-4(IL-4) ELISA Kit coming soon

Inquiry

IL-6CRS-A005Human Interleukin-6(IL-6) ELISA Kit coming soon

Inquiry

IL-7CRS-A006Human Interleukin-7(IL-7) ELISA Kit coming soon

Inquiry

IL-8CRS-A007Human Interleukin-8(IL-8) ELISA Kit coming soon

Inquiry

IL-10CRS-A008Human Interleukin-10(IL-10) ELISA Kit coming soon

Inquiry

IL-15CRS-A009Human Interleukin-15(IL-15) ELISA Kit coming soon

Inquiry

IL-21CRS-A010Human Interleukin-21(IL-21) ELISA Kit coming soon

Inquiry

IL-12p70CRS-A011Human Interleukin-12p70(IL-12p70) ELISA Kit coming soon

Inquiry

IL-1betaCRS-A012Human Interleukin-1beta(IL-1beta) ELISA Kit coming soon

Inquiry

GM-CSFCRS-A013Human Macrophage Colony Stimulating Factor 2(GM-CSF) ELISA Kit coming soon

Inquiry

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