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> Organs-on-Chips 
Introduction
Organs-on-Chips Products
NeuroFluidics™
NeuroFluidic MEA™
MultiFluidics™
Organs-on-Chips Starter Kits
Training and Technical Support
•Microfluidic Compartmentalization: Enables spatial segregation of neuronal subtypes or regions, supporting the formation of directional neural networks.
•Standardized High-Throughput Format: NeoBento adopts a standard ANSI format, ensuring broad compatibility and easy handling, just like a 96-well plate.
•Compatible with Various Neural Cell Types: Suitable for primary neurons, iPSC-derived neurons, microglia, and co-culture systems to meet diverse experimental needs.
•Supports Complex Neural Circuit Modeling: Designed to guide axon growth, promote synapse formation, and facilitate signal transmission for functional neural network reconstruction.
•Ideal for Degenerative Disease Research: Enables long-term culture and neural injury modeling to study neuroinflammation and degenerative pathology.
DuaLink MEA Schematic: The device features three channels, with Culture Channel 1 and Culture Channel 3 for cell culture and Central Microchannel 2 for fluidic isolation. MEA electrodes are positioned at the bottom to directly interface with cultured neurons.
•Integration of MEA and Microfluidics: Enables simultaneous electrical signal recording and fluid manipulation during neural cell culture.
•Precise Capture of Neural Network Activity: High-density MEA allows real-time, non-invasive recording of action potentials, local field potentials, and network bursts.
•Multi-Tissue Co-Culture Capability: Enables simultaneous culture of various cell types (e.g., liver, kidney, intestine, and immune cells), supporting the simulation of complex physiological processes.
•Physiologically Relevant Fluid Dynamics: Recreates circulatory system-like flow conditions to more accurately simulate tissue perfusion and shear stress in vivo.
•Scalable Architecture: Suitable for single-organ studies, with the ability to scale up to multi-organ chip systems, supporting both low-throughput and high-throughput experimental needs.
•4 QuarterBentos (chip options available)
•2 NeoBento LIGHT
•Microfluidic training and 1-hour technical support session
•Available on demand with Rodent DRG (Dorsal Root Ganglion)
•4 QuarterBentos (chip options available)
•2 NeoBento MEA EDGE
•Microfluidic & MEA training with 1-hour technical support session
•Available on demand with Rodent DRG (Dorsal Root Ganglion)
Product List
| Product Type | Cat. No. | Description |
| NeuroFluidics ™ | NFDL-1 | NeuroFluidics NeoBento Dualink LIGHT (Acro Certified) |
| NFDL-2 | NeuroFluidics NeoBento Dualink FULL (Acro Certified) | |
| NFDLS-1 | NeuroFluidics NeoBento Dualink SHIFT LIGHT (Acro Certified) | |
| NFDLS-2 | NeuroFluidics NeoBento Dualink SHIFT FULL (Acro Certified) | |
| NFTL-1 | NeuroFluidics NeoBento Trialink LIGHT (Acro Certified) | |
| NFTL-2 | NeuroFluidics NeoBento Trialink FULL (Acro Certified) | |
| NeuroFluidics ™ MEA | NFDLMEA-3 | NeuroFluidics NeoBento DuaLink MEA EDGE (Acro Certified) |
| NFDLMEA-4 | NeuroFluidics NeoBento Dualink MEA PRO (Acro Certified) | |
| NFDLSMEA-3 | NeuroFluidics NeoBento DuaLink SHIFT MEA EDGE (Acro Certified) | |
| NFTLMEA-3 | NeuroFluidics NeoBento Trialink MEA EDGE (Acro Certified) | |
| NFTLMEA-4 | NeuroFluidics NeoBento Trialink MEA PRO (Acro Certified) | |
| MultiFluidics ™ | MFDW-1 | Neobento Multifluidics DUPLEX LIGHT (Acro Certified) |
| MFDW-2 | Neobento Multifluidics DUPLEX FULL (Acro Certified) | |
| Organs-on-chip kits | NFKSNDL-3 | NeuroFluidics Sensory Neurons Kit (Acro Certified) |
| NFKSNDLMEA-3 | NeuroFluidics Sensory Neurons MEA Kit (Acro Certified) | |
| NFKDL-3 | NeuroFluidics DuaLink Starter Kit (Acro Certified) | |
| NFKDLMEA-3 | NeuroFluidics DuaLink MEA Starter Kit (Acro Certified) | |
| Training | ONLINE-UT | Online Uplink Training (Acro Certified) |
| ONLINE-MF | Online Microfluidics Training (Acro Certified) | |
| ONSITE-MF | Onsite Microfluidics Training (Acro Certified) |
Case Study
A. Immunofluorescence staining images of rat hippocampal neurons (Culture Channel 1) and cortical neurons (Culture Channel 3). Neurons successfully attached to the culture channels and extended axons. DAPI stains nuclei (blue), β-III-tubulin marks cell bodies and axons (green), and MAP2 labels dendrites (red). Scale bar = 500 µm.
B. Brightfield image of the rat neuron co-culture system on day 15, showing clear axonal extension.
C. Raster plots of the co-culture system on days 7, 14, and 21 (recording duration: 300 seconds). Synchronized firing activity began on day 14 and became more pronounced by day 21, indicating gradual network maturation.
D. Comparison of the mean firing rate (MFR) between the culture channels and connecting microchannel on days 7, 14, and 21. MFR increased significantly over time. On day 14, higher spontaneous activity (0.8 spikes/s) was observed in the microchannel, compared to 0.3 spikes/s in the culture channels, suggesting faster functional development of axonal pathways in the microchannel.
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