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Your Position: Home > CD16A / FCGR3A Molecule

CD16a / FCGR3A Molecule Synonym Name


CD16a / FCGR3A Protein Products

Cat No Species Product Description
CD8-H52H4 Human Human FCGR3A / CD16a (V176) Protein
CDA-H5220 Human Human FCGR3A / CD16a (F176) Protein
CDA-H82E8 Human Biotinylated Human Fc gamma RIIIA / CD16a (F176), Avi Tag (Avitag™)
CDA-H82E9 Human Biotinylated Human Fc gamma RIIIA / CD16a (V176), Avi Tag (Avitag™)
CDA-M52H8 Mouse Mouse FCGR3A / CD16a Protein

CD16a / FCGR3A Molecule Background

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody?dependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.


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