>IL23A & IL12B Molecule
IL-23 alpha & IL-12 beta
|Cat No||Species||Product Description|
|ILB-H52W5||Human||Human IL-23 alpha & IL-12 beta Heterodimer Protein|
|ILB-HM52W6||Human & Mouse||Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein|
|ILB-M52W7||Mouse||Mouse IL-23 alpha & IL-12 beta Heterodimer Protein|
|ILB-H82W6||Human||Biotinylated Human IL-23 alpha & IL-12 beta, Avi Tag (Avitag™)|
Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
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