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1. Clear MoA. T cells are activated to eliminate tumor cells by targeting BAFFR. BAFFR×CD3 bsAb treats the CD19-resistant or CD20-resistant B-cell malignancies.
2. Significant clinical efficacy and low toxicity & side effects.
a) 2:1(TAA:CD3) structure, high binding to TAA, relative low affinity to CD3, reduce non-specific T cell activation.
b) Human single domain antibody for TAA, stable as Nano antibody, with low immunogenicity.
c) High efficacy in-vitro and in-vivo.
d) Long PK in-vivo with Fc (t1/2=13.7 days).
3. Global competitiveness.
a) FIC potential. No similar competing drugs, and few study on BAFFR antibody in B lymphocyte carcinoma indications. The guideline for the treatment of B-lymphocyte cancer has great side effects and is easy to be resistant to drugs.
b) Stable enough for downstream development.
1. Asset type: BAFFR×CD3 bsAb
2. Modality: bsAb, fully human antibody
3. Indication: B cell malignancies/autoimmune diseases
4. Research phase: CMC development
5. Research progress：
1) Complete the anti-BAFFR Screening.
2) BAFFR-CD3 bsAb cytotoxic activity in vitro shows the killing activity against jeko-1-luci cells.
3) BAFFR-CD3 bsAb cytotoxic activity in vivo. In the PBMC transplanted tumor model, showed excellent in vivo efficacy in both high and low dose groups (10 mg/kg;1 mg/kg). After four doses, the tumors of both mice disappeared.
ACROBiosystems offers a wide selection of Matrigengel basement membrane extracts. Different versions – including phenol red-free, high concentration, iPSC culturing, organoid culturing – are all available for your specific needs to support 3D cell culture!
To enable antibody characterization methodsACROBiosystems has developed a series of enzymes.such as ldeS, SpeB, EndoH, and Endo S proteases, toassist with the characterization of antibodies and theirrelated post-translational modifications (PTMs)
ComboX is a new brand of ACROBiosystems. ComboX products include our Streptavidin series products, coated plates, isotype controls for antibody and fusion protein drug research, and general-purpose antibodies.
50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
ACROBiosystems developed a series of GMP grade cytokines under the GMP grade quality management system. Those products are all suitable for T/NK cell generation, activation, and proliferation in cell therapy research.
GMP grade cytokines, reagents for cell activation, gene edition, DNA/RNA removal, etc. Particularly focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey.
Full length multi-pass TPs with stabilized structure and high bioactivity for immunization, antibody screening, cell based assay and CAR detection, including hot CD20, Claudin 18.2， CD133, GPRC5D，CCR8, CCR5, etc.
A series of immune checkpoints including classic co-inhibitory and co-stimulatory receptors. The comprehensive catalog contains 100+ targets with various species and tags, and the high-quality proteins are in good batch-to-batch consistency.
To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
Comprehensive collection of Fc receptor proteins, including their common variants, which can help expedite your antibody development.
Comprehensive cytokine targets including interleukins, growth factors, chemokines, TNFs, etc. are expressed by HEK293 to ensure their natural structure. Their high purity is verified by SDS-PAGE/HPLC/SEC-MALS and high bioactivity is verified by ELISA/SPR/BLI.
Aneuro is ACROBiosystems brand focused on neuroscience research, providing high-quality important proteins including therapeutic and diagnostic research proteins, PFFs and recombinant neuro factors, etc. to advance neuroscience research.
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