1. Clear MoA.
(1). CD19 is expressed on nearly all B-cell malignancies: including ALL, CLL, many NHL (>95%).
(2). CD37 is expressed on mature B cells ,but it expressed at very low levels in T cells, macrophages, monocytes and dendritic cells.
2. High affinity.
3. High efficacy in-vitro.
(1). Specific cell killing activity and high cytokine production on CD37 positive cancer cell.
(2). Specific cell killing activity and high cytokine production on CD19 positive cancer cell.
4. CD19+CD37 CAR-T Significantly reduces Raji tumor growth, prolongs survival in mice.
1. Asset type: CD19 + CD37 CAR-T
2. Indication: NHL, Leukemia
3. Research phase: Pre-clinical
4. Cooperation demands: License-out or co-development
5. Research progress：
1) Complete the CD19+CD37 CAR-T Screening.
2) CD19+CD37 CAR-T activity in vitro and in vivo showed the high killing activity against many CD19 or CD37 positive cancer cells.
3) CD19+CD37 CAR-T co-incubated with Hela CD19+ cells secreted less IFN-γ than CD19 CAR-T, thus may low risk of “cytokine storm”.
4) CD19+CD37 CAR-T significantly prolonged the survival of tumor-bearing mice. After 7 weeks of treatment, no mice died.
ComboX is a new brand of ACROBiosystems. ComboX products include our Streptavidin series products, coated plates, isotype controls for antibody and fusion protein drug research, and general-purpose antibodies.
Emerging VoCs, Omicron, Delta, Beta, Alpha mutants and so on, including RBD, S trimer, S1, NTD, NP, etc. These mutants are of high purity and bioactivity and can be used to evaluate the efficacy of the antibodies and vaccination.
ACROBiosystems developed a series of GMP grade cytokines under the GMP grade quality management system. Those products are all suitable for T/NK cell generation, activation, and proliferation in cell therapy research.
50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
GMP grade cytokines, reagents for cell activation, gene edition, DNA/RNA removal, etc. Particularly focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey.
Full length multi-pass TPs with stabilized structure and high bioactivity for immunization, antibody screening, cell based assay and CAR detection, including hot CD20, Claudin 18.2， CD133, GPRC5D，CCR8, CCR5, etc.
CD3 proteins and a collection of for bispecific antibody development which are of high specificity and bioactivities and suitable for immunization, antibody screening.
A series of immune checkpoints including classic co-inhibitory and co-stimulatory receptors. The comprehensive catalog contains 100+ targets with various species and tags, and the high-quality proteins are in good batch-to-batch consistency.
To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
Comprehensive collection of Fc receptor proteins, including their common variants, which can help expedite your antibody development.
Comprehensive cytokine targets including interleukins, growth factors, chemokines, TNFs, etc. are expressed by HEK293 to ensure their natural structure. Their high purity is verified by SDS-PAGE/HPLC/SEC-MALS and high bioactivity is verified by ELISA/SPR/BLI.
Aneuro is ACROBiosystems brand focused on neuroscience research, providing high-quality important proteins including therapeutic and diagnostic research proteins, PFFs and recombinant neuro factors, etc. to advance neuroscience research.
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