1. Clear MoA.
(1). Higher IL10 level in severe CRS, sepsis and HLH patients.
(2). Blocking IL10/IL10R signaling pathway is a new strategy of treating CRS, HLS, and sepsis.
lt is reported that a high ratio of lLl0 to TNFα correlated with mortality in patients (464 cases) with community-acquired infection.
2. Sepsis: high mortality (19 million patients, the mortality rate >25%), huge market size ($ 3.2 billion in 2018, with a CAGR of 7.5%).
3. Unique fully human mAb with low immunogenicity.
4. ADCC and ADCP silenced lgG4 ensures antibody safety.
5. Superior stability and good druggability.
After 6 times of frozen-thawing or storage at 40°C for 4 weeks, the activity of the candidate did not change significantly.
6. Both mAbs have blocking activity on lL10/IL10RA signal pathway, and the efficacy can be seen in the sepsis modeling mouse.
1. Asset type: IL10 / IL10RA mAb
2. Indication: Sepsis/ HLH/ CRS
3. Modality: fully human mAb, ADCC and ADCP silenced lgG4
4. Research phase: Ready for CMC development
5. Cooperation demands: License-out or co-development
6. Research progress：
(1). IL10 / IL10RA mAb showed excellent stability and good druggability.
(2). Ready for CMC development.
(3). IL10 / IL10RA mAb significantly prolonged the survival of mice with LPS-induced sepsis (90 % vs 30 %).
ComboX is a new brand of ACROBiosystems. ComboX products include our Streptavidin series products, coated plates, isotype controls for antibody and fusion protein drug research, and general-purpose antibodies.
Emerging VoCs, Omicron, Delta, Beta, Alpha mutants and so on, including RBD, S trimer, S1, NTD, NP, etc. These mutants are of high purity and bioactivity and can be used to evaluate the efficacy of the antibodies and vaccination.
ACROBiosystems developed a series of GMP grade cytokines under the GMP grade quality management system. Those products are all suitable for T/NK cell generation, activation, and proliferation in cell therapy research.
50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
GMP grade cytokines, reagents for cell activation, gene edition, DNA/RNA removal, etc. Particularly focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey.
Full length multi-pass TPs with stabilized structure and high bioactivity for immunization, antibody screening, cell based assay and CAR detection, including hot CD20, Claudin 18.2， CD133, GPRC5D，CCR8, CCR5, etc.
CD3 proteins and a collection of for bispecific antibody development which are of high specificity and bioactivities and suitable for immunization, antibody screening.
A series of immune checkpoints including classic co-inhibitory and co-stimulatory receptors. The comprehensive catalog contains 100+ targets with various species and tags, and the high-quality proteins are in good batch-to-batch consistency.
To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
Comprehensive collection of Fc receptor proteins, including their common variants, which can help expedite your antibody development.
Comprehensive cytokine targets including interleukins, growth factors, chemokines, TNFs, etc. are expressed by HEK293 to ensure their natural structure. Their high purity is verified by SDS-PAGE/HPLC/SEC-MALS and high bioactivity is verified by ELISA/SPR/BLI.
Aneuro is ACROBiosystems brand focused on neuroscience research, providing high-quality important proteins including therapeutic and diagnostic research proteins, PFFs and recombinant neuro factors, etc. to advance neuroscience research.
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