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1. Clear MoA.
1)TIM3 is an inhibitory immune checkpoint that is expressed on the surface of T cells, DCs, Treg cells and other innate immune cells, and can cause T cell exhaustion and tumor immune escape.
2)Patients with TIM3 overexpressing show ineffective anti-PD1 therapy.
3)Dual-blockade of TIM3 and PD1 can significantly activate antitumor effects.
2. TIM3 × PD1 bsAb is the first to simultaneously release the inhibitory activity of DCs, T cells, and NK cells.
1) Significantly activate the tumor-killing activity of NK cells
2) Restore DCs antigen-presenting ability and T cells tumor-killing activity
3. high binding affinity.
1) Anti-PD-1 effect in liver cancer is comparable to Keytruda（77-88%TGI）;
2) Anti-TIM3 ability is stonger than RG7769;
3) Anti-TIM3 ability of the BsAb is comparable to anti-PD-1（approximated 5-8nM）.
4. BsAb shows high antitumor activity in PD1 insensitive mouse model and at the day 40 the survival ratio reachs to 85% which is superior to a combination of anti-TIM3 and anti-PD1 due to synergistic effects.
5. Good PK/PD property.
1) HNSTD=200 mpk;
2) At the dose of 2、10、50 mpk，ADA=33.3%(2/6)、83.3%(5/6)and 0.0%(0/6);
3) At the dose of 2-50 mpk，t1/2=31.7-66.5 h.
1. Asset type: TIM3×PD-1 bsAb
2. Indication: Solid Tumor
4. Research phase: Phase 1
5. Cooperation demands: License-out or co-development
6. Research progress：
1) Got document for clinical trials in China and USA, Phase Ⅰ in China and have plans of second or third treatment for NSCLC(10 patients).
2) The pre-clinical data is more competitive than other products in clinical.
3) Inhibit tumor growth in PD-1 insensitive model, prolong survival ratio and its effectiveness is better than solitary drug or combination.
4) Good safety and PK/PD property.
ACROBiosystems offers a wide selection of Matrigengel basement membrane extracts. Different versions – including phenol red-free, high concentration, iPSC culturing, organoid culturing – are all available for your specific needs to support 3D cell culture!
To enable antibody characterization methodsACROBiosystems has developed a series of enzymes.such as ldeS, SpeB, EndoH, and Endo S proteases, toassist with the characterization of antibodies and theirrelated post-translational modifications (PTMs)
ComboX is a new brand of ACROBiosystems. ComboX products include our Streptavidin series products, coated plates, isotype controls for antibody and fusion protein drug research, and general-purpose antibodies.
50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
ACROBiosystems developed a series of GMP grade cytokines under the GMP grade quality management system. Those products are all suitable for T/NK cell generation, activation, and proliferation in cell therapy research.
GMP grade cytokines, reagents for cell activation, gene edition, DNA/RNA removal, etc. Particularly focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey.
Full length multi-pass TPs with stabilized structure and high bioactivity for immunization, antibody screening, cell based assay and CAR detection, including hot CD20, Claudin 18.2， CD133, GPRC5D，CCR8, CCR5, etc.
A series of immune checkpoints including classic co-inhibitory and co-stimulatory receptors. The comprehensive catalog contains 100+ targets with various species and tags, and the high-quality proteins are in good batch-to-batch consistency.
To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
Comprehensive collection of Fc receptor proteins, including their common variants, which can help expedite your antibody development.
Comprehensive cytokine targets including interleukins, growth factors, chemokines, TNFs, etc. are expressed by HEK293 to ensure their natural structure. Their high purity is verified by SDS-PAGE/HPLC/SEC-MALS and high bioactivity is verified by ELISA/SPR/BLI.
Aneuro is ACROBiosystems brand focused on neuroscience research, providing high-quality important proteins including therapeutic and diagnostic research proteins, PFFs and recombinant neuro factors, etc. to advance neuroscience research.
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