Can’t find what you’re looking for? Fill out this form to inquire about our custom protein services!
Inquire about our Custom Services >>
Order Online! Now! Get your $50 coupon for online order. 
Order Online! Now! Get your $50 coupon for online order.
Get your basement membrane extract free sample to test now! Get your basement membrane extract free sample to test now!
Time Limited Offer: Welcome Gift for New Customers ! Shipping Price Reduction for EU Regions
1. Clear MoA.
1) LAG-3 belongs to the immunoglobulin (Ig) superfamily, it is a type I transmembrane protein with structural similarities to CD4.
2) LAG-3 is extensively expressed on activated T cells and NK cells，also expressed on activated B cells and plasma cell-like dendritic cells (pDCs).
3) LAG-3 is an inhibitory immune checkpoint for T cells, and like PD-1 and CTLA-4, LAG-3 negatively regulates the proliferation, activation, and homeostasis of T cells. It is a novel target for cancer and autoimmune disorders.
2. Excellent preclinical efficacy:
1) The binding activity of this LAG-3 mAb to human activated CD4 T cells is slightly higher than that of the positive control drug BH98 (Relatlimab analogue).
2) The blocking effect on FGL1 is higher than that of BH98.
3. Similar tumor-killing activity as Relatlimab (BH98) in vivo.
4. The combination of LAG-3 mAb and PD-1 can synergistically enhance the anti-tumor effect, better than monotherapy.
5. Excellent safety
1) NOAEL= 100 mg/kg.
2) No immunotoxicity: no ADCC activity
3) Plasma cytokine concentrations (IFNγ, TNFα, IL6, IL1β, IL2, IL4) were not abnormally increased after mAb administration.
4) No hemolytic effect.
1. Asset type: LAG-3 mAb
2. Indication: Advanced solid tumors
3. Research phase: Phase 1
4. Cooperation demands: License-out or co-development
5. Research progress：
1. Completed preclinical development
2. Phase I clinical trials are ongoing to evaluate the safety, tolerability, pharmacokinetics and efficacy of candidate antibodies for advanced malignancies.
ACROBiosystems offers a wide selection of Matrigengel basement membrane extracts. Different versions – including phenol red-free, high concentration, iPSC culturing, organoid culturing – are all available for your specific needs to support 3D cell culture!
To enable antibody characterization methodsACROBiosystems has developed a series of enzymes.such as ldeS, SpeB, EndoH, and Endo S proteases, toassist with the characterization of antibodies and theirrelated post-translational modifications (PTMs)
ComboX is a new brand of ACROBiosystems. ComboX products include our Streptavidin series products, coated plates, isotype controls for antibody and fusion protein drug research, and general-purpose antibodies.
50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
ACROBiosystems developed a series of GMP grade cytokines under the GMP grade quality management system. Those products are all suitable for T/NK cell generation, activation, and proliferation in cell therapy research.
GMP grade cytokines, reagents for cell activation, gene edition, DNA/RNA removal, etc. Particularly focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey.
Full length multi-pass TPs with stabilized structure and high bioactivity for immunization, antibody screening, cell based assay and CAR detection, including hot CD20, Claudin 18.2， CD133, GPRC5D，CCR8, CCR5, etc.
A series of immune checkpoints including classic co-inhibitory and co-stimulatory receptors. The comprehensive catalog contains 100+ targets with various species and tags, and the high-quality proteins are in good batch-to-batch consistency.
To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
Comprehensive collection of Fc receptor proteins, including their common variants, which can help expedite your antibody development.
Comprehensive cytokine targets including interleukins, growth factors, chemokines, TNFs, etc. are expressed by HEK293 to ensure their natural structure. Their high purity is verified by SDS-PAGE/HPLC/SEC-MALS and high bioactivity is verified by ELISA/SPR/BLI.
Aneuro is ACROBiosystems brand focused on neuroscience research, providing high-quality important proteins including therapeutic and diagnostic research proteins, PFFs and recombinant neuro factors, etc. to advance neuroscience research.
This web search service is supported by Google Inc.
A-Z
