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1. Huge drug market for HBV
(1) In 2016 global HBV prevalence is 3.9%, with 292m cases, within which 32% of cases need therapies. In 2017, 870,000 people have been dead from HBV. 25% of HBV patients develop HCC.
(2) Patients receiving Long-term treatment with the current therapies easily relapse after off-treatment. And uncleared HBsAg causes an unexpected immune reaction for a long time. A low functional cure rate is a big challenge for HBV therapy, and new strategies are in need to reform HBV therapy.
2. Capsid assembly inhibitors are a viable strategy for HBV
Capsid assembly inhibitors bind to the dimer-dimer interface and disrupt the formation of functional nucleocapsids, blocking several steps of the HBV life cycle including entry, replication, assembly, and secretion and preventing maturation of infectious viral particles.
3. Asset efficiently disturbing capsid assembly and synthesis and inhibiting cccDNA formation in vitro.
(1) Asset increased the proportion of misshapen particles similar to Bay41-4109.
(2) Asset treatment led to HBcAg aggregation and accelerated intracellular HBcAg degradation and inhibited the synthesis of capsids.
(3) In the HepG2-NTCP-expressing cell line, the asset showed a stronger cccDNA formation inhibition compared to Bay41-4109.
4. Excellent active against NA-resistant HBV.
Asset demonstrates Inhibitory activity in serval NA-resistance HBVmuts. Compared with current NA drugs, the asset remains a broader applicable patient.
5. Cheerful clinical trial date: successfully decreasing in HBsAg and HBeAg levels, respectively.
(1) Phase IIa study showed 0.4log and 1.0log reduction in HBsAg and HBeAg levels, respectively, with 24 weeks of treatment.
(2) The combination of asset and ETV in the phase IIb study accelerated HBV DNA reduction. 0.4log and 0.5log average reduction in HBsAg and HBeAg levels, respectively, with 12 weeks of treatment. Deeper inhibition of HBV replication and HBsAg increases the chance of functional cure in the long run.
1. Asset type: Capsid Assembly Inhibitors for HBV
2. Indication: HBV
3. Research phase: Phase 3 China, Phase 2, US
4. Cooperation demands: License-out or co-development
5. Research progress：
(1) Phase 3 trial is ongoing.
(2) Cheerful phase II results with high expectations for functional cure in long run based on the clinical trial.
(3) Demonstrated inhibitory activity in serval NA-resistance HBVmuts.
ACROBiosystems offers a wide selection of Matrigengel basement membrane extracts. Different versions – including phenol red-free, high concentration, iPSC culturing, organoid culturing – are all available for your specific needs to support 3D cell culture!
To enable antibody characterization methodsACROBiosystems has developed a series of enzymes.such as ldeS, SpeB, EndoH, and Endo S proteases, toassist with the characterization of antibodies and theirrelated post-translational modifications (PTMs)
ComboX is a new brand of ACROBiosystems. ComboX products include our Streptavidin series products, coated plates, isotype controls for antibody and fusion protein drug research, and general-purpose antibodies.
50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
ACROBiosystems developed a series of GMP grade cytokines under the GMP grade quality management system. Those products are all suitable for T/NK cell generation, activation, and proliferation in cell therapy research.
GMP grade cytokines, reagents for cell activation, gene edition, DNA/RNA removal, etc. Particularly focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey.
Full length multi-pass TPs with stabilized structure and high bioactivity for immunization, antibody screening, cell based assay and CAR detection, including hot CD20, Claudin 18.2， CD133, GPRC5D，CCR8, CCR5, etc.
A series of immune checkpoints including classic co-inhibitory and co-stimulatory receptors. The comprehensive catalog contains 100+ targets with various species and tags, and the high-quality proteins are in good batch-to-batch consistency.
To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
Comprehensive collection of Fc receptor proteins, including their common variants, which can help expedite your antibody development.
Comprehensive cytokine targets including interleukins, growth factors, chemokines, TNFs, etc. are expressed by HEK293 to ensure their natural structure. Their high purity is verified by SDS-PAGE/HPLC/SEC-MALS and high bioactivity is verified by ELISA/SPR/BLI.
Aneuro is ACROBiosystems brand focused on neuroscience research, providing high-quality important proteins including therapeutic and diagnostic research proteins, PFFs and recombinant neuro factors, etc. to advance neuroscience research.
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