1. Clear MOA
(1) Orexins bind and activate their associated G protein-coupled OX1Rs and OX2Rs and act on sleep-wake regulation.
(2) Antagonism of the orexin system increases NREM and REM sleep, decreases anxiety- and panic-like behaviors, and inhibits the reinforcing and motivational properties of addictive drugs.
(3) Inhibition of ACC enzymes pharmacologically provides an attractive approach to treating NAFLD/NASH by decreasing hepatic lipid synthesis while simultaneously increasing fatty acid oxidation.
(4) OX1Rs and OX2Rs play differential roles in the regulation of REM sleep and NREM sleep. NREM sleep is mainly regulated by OX2Rs.
2. High selective dual inhibition.
The antagonistic effect of the asset on OX2R is better than that on OX1R.
3. Treat insomnia: Significantly increases NREM time, decreases NREM latency and wakefulness time without affecting REM time in rats and cynomolgus monkeys.
4. After 12h administration (light on), the asset has no effect on NREM or wakefulness, showing slight residual effect of the next day.
5. Good safety:
(1) There is no significant correlation between the incidence of AEs and the dose.
(2) No SAEs, no TEAE leading to early withdrawal from the test or death.
6. High incidence
1. Asset type: High selective OX1R/OX2R dual inhibitor treating insomnia
2. Indication: Insomnia
3. Modality: Small molecular, orally QD, first class new medicine
4. Research phase: Phase Ⅰ completed, IP has been granted in the US, CN, etc
5. Cooperation demands: License-out or co-development the global right
6. Research progress:
(1) The asset has completed phase 1 trial.
(2) Slight residual effect of the next day
(3) Good efficacy without affecting REM time.
ComboX is a new brand of ACROBiosystems. ComboX products include our Streptavidin series products, coated plates, isotype controls for antibody and fusion protein drug research, and general-purpose antibodies.
Emerging VoCs, Omicron, Delta, Beta, Alpha mutants and so on, including RBD, S trimer, S1, NTD, NP, etc. These mutants are of high purity and bioactivity and can be used to evaluate the efficacy of the antibodies and vaccination.
ACROBiosystems developed a series of GMP grade cytokines under the GMP grade quality management system. Those products are all suitable for T/NK cell generation, activation, and proliferation in cell therapy research.
50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
GMP grade cytokines, reagents for cell activation, gene edition, DNA/RNA removal, etc. Particularly focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey.
Full length multi-pass TPs with stabilized structure and high bioactivity for immunization, antibody screening, cell based assay and CAR detection, including hot CD20, Claudin 18.2， CD133, GPRC5D，CCR8, CCR5, etc.
CD3 proteins and a collection of for bispecific antibody development which are of high specificity and bioactivities and suitable for immunization, antibody screening.
A series of immune checkpoints including classic co-inhibitory and co-stimulatory receptors. The comprehensive catalog contains 100+ targets with various species and tags, and the high-quality proteins are in good batch-to-batch consistency.
To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
Comprehensive collection of Fc receptor proteins, including their common variants, which can help expedite your antibody development.
Comprehensive cytokine targets including interleukins, growth factors, chemokines, TNFs, etc. are expressed by HEK293 to ensure their natural structure. Their high purity is verified by SDS-PAGE/HPLC/SEC-MALS and high bioactivity is verified by ELISA/SPR/BLI.
Aneuro is ACROBiosystems brand focused on neuroscience research, providing high-quality important proteins including therapeutic and diagnostic research proteins, PFFs and recombinant neuro factors, etc. to advance neuroscience research.
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A-Z
FLAG
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ViruStop
Aneuro
ComboX
ActiveMax
GENPower
ClinMax 
Star Ribbon 
