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EphA4

EphA4 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
EP4-H52H8 Human Human EphA4 Protein, His Tag
EP4-H52H8-structure
EP4-H52H8-sds
EP4-H52H8-elisa_1

EphA4 Part of Bioactivity data

EP4-H52H8-ELISA
Human EphA4, His TagHuman EphA4, His Tag (Cat. No. EP4-H52H8) ELISA bioactivity

Immobilized Human EphA4, His Tag (Cat. No. EP4-H52H8) at 5 μg/mL (100 μL/well) can bind Human Ephrin-A4, Fc Tag (Cat. No. EA4-H5250) with a linear range of 0.6-5 ng/mL (QC tested).

EphA4 Molecule Synonym Name

EphA4,HEK8,SEK,TYRO1,EK8

EphA4 Molecule Background

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

EphA4 References

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