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Brief Information

Name:Erythropoietin-producing hepatocellular receptor A4
Target Synonym:Ephrin type-A receptor 4,EPH-like kinase 8 (EK8; hEK8),Tyrosine-protein kinase TYRO1,Tyrosine-protein kinase receptor SEK,EPH Receptor A4,TYRO1,HEK8,Tyrosine-Protein Kinase Receptor SEK,Tyrosine-Protein Kinase TYRO1,Ephrin Type-A Receptor 4,EPH-Like Kinase 8,EC,EK8,SEK,Receptor Protein-Tyrosine Kinase HEK8,TYRO1 Protein Tyrosine Kinase,EC 2.7.10
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
EP4-H52H8 Human Human EphA4 Protein, His Tag
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Part of Bioactivity data


Immobilized Human EphA4, His Tag (Cat. No. EP4-H52H8) at 5 μg/mL (100 μL/well) can bind Human Ephrin-A4, Fc Tag (Cat. No. EA4-H5250) with a linear range of 0.6-5 ng/mL (QC tested).

Synonym Name



Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
mEphA4-Fc mEphA4-Fc Phase 1 Clinical Queensland Brain Institute Nerve Degeneration; Nervous System Diseases; Amyotrophic Lateral Sclerosis Details
E2025 E-2025; E2025 Phase 1 Clinical Eisai Inc Alzheimer Disease Details

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