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Your Position: Home > CD6


Brief Information

Name:T-cell differentiation antigen CD6
Target Synonym:T12,CD6,CD6 Molecule,TP120,T-Cell Differentiation Antigen CD6,CD6 Antigen
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

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Part of Bioactivity data


Immobilized Biotinylated Cynomolgus CD6 Protein, His,Avitag (Cat. No. CD6-C82E3) at 1 μg/mL (100 μL/well) on streptavidin precoated (0.5 μg/well) plate can bind Human ALCAM, Fc Tag (Cat. No. CD6-H5259) with a linear range of 0.3-2 ng/mL (QC tested).

CD6 MALS images

The purity of Cynomolgus CD6 Protein, His Tag (Cat. No. CD6-C52H3) is more than 90% and the molecular weight of this protein is around 80-100 kDa verified by SEC-MALS.

Synonym Name



CD6 (Cluster of Differentiation 6) is a cell surface glycoprotein that is involved in T cell activation and a member of the scavenger receptor cysteine rich protein superfamily (SRCRSF). CD6 is expressed at low levels on immature thymocytes and at high levels on mature thymocytes. The majority of peripheral blood T cells, a subset of B cells, and a subset of neuronal cells express CD6. CD6 appears to play a role as both a costimulatory molecule in T cell activation and as an adhesion receptor. Studies demonstrating a mitogenic effect for T cells with some CD6 specific monoclonal antibodies, in conjunction with either accessory cells or PMA and anti-CD2 mAb, support the concept of CD6 as a co stimulatory molecule.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Itolizumab T-1-hT; EQ-001; T-1-h; h-T1; Bmab-600 Approved Biocon Ltd, Center Of Molecular Immunology, Biotech Pharmaceuticals Co Ltd Alzumab India Plaque psoriasis Biocon Ltd 2013-01-01 Dermatomyositis; Graft vs Host Disease; Lupus Erythematosus, Cutaneous; Coronavirus Disease 2019 (COVID-19); Respiratory Distress Syndrome, Adult; Lupus Nephritis; Psoriasis; Asthma; Plaque psoriasis Details

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