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TSHR

TSHR Molecule Information

Name:Thyroid stimulating hormone receptor
Target Synonym:TSHR?Thyroid Stimulating Hormone Receptor?LGR3?Thyroid-Stimulating Hormone Receptor?Seven Transmembrane Helix Receptor?Thyrotropin Receptor-I? HTSHR-I?Thyrotropin Receptor?TSH Receptor?HTSHR-I?TSH-R?Receptors? Thyrotropin?CHNG1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

TSHR Molecule Synonym Name

TSHR,TSH-R,LGR3,TSH R

TSHR Molecule Background

Thyroid-stimulating hormone receptor (TSHR) is also known as Thyrotropin receptor and LGR3. TSHR is glycosylated receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.

TSHR References

TSHR Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Thyrotropin alfa rh-TSH; MRrhTSH; rhTSH-M Approved Genzyme Corp Thyrogen Japan Thyroid Neoplasms s:20:"Genzyme Corp, Sanofi"; 1998-11-30 Thyroid Neoplasms; Diagnostic agents Details

TSHR Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant human thyrotropin (Zelgen Biosciences) Phase 2 Clinical Suzhou Zelgen Biosciences Co Ltd Thyroid Neoplasms Details
ICTCAR023 ICTCAR023 Phase 1 Clinical Innovative Cellular Therapeutics Co Ltd Thyroid Neoplasms Details
Anti-thyroid stimulating hormone receptor chimeric antigen receptor T cell therapy (Innovative Cellular Therapeutics) ICTCAT-023 Phase 2 Clinical Innovative Cellular Therapeutics Co Ltd Thyroid Neoplasms Details

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