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S1 protein

S1 protein Part of Bioactivity data


Loaded Human ACE2, Fc Tag (MALS verified) (Cat. No. AC2-H5257) on Protein A Biosensor, can bind 2019-nCoV (COVID-19) S1 protein, His Tag (Cat. No. S1N-C52H3) with an affinity constant of 21.8 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

SARS S1 protein, His TagSARS S1 protein, His Tag (Cat. No. S1N-S52H5) ELISA bioactivity

Immobilized SARS S1 protein, His Tag (Cat. No. S1N-S52H5) at 2 μg/mL (100 μL/well) can bind Human ACE2, Fc Tag (Cat. No. AC2-H5257) with a linear range of 0.4-8 ng/mL (QC tested).

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S1 protein Molecule Synonym Name

S1 protein,Spike glycoprotein Subunit1,S glycoprotein Subunit1,Spike protein S1,COVID-19

S1 protein Molecule Background

Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

S1 protein References

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