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ACE2

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Cat. No. Species Product Description Structure Purity Feature
CHEK-ATP042 - HEK293/Human ACE2 Overexpression Stable Cell Line
CHEK-ATP042-sds
AC2-HR2H0 Human HRP-Human ACE2 / ACEH Protein, Fc Tag
AC2-HR2H0-structure
AC2-HR2H0-elisa_1
AC2-H82E8 Human Biotinylated Monomeric Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)
AC2-H82E8-structure
AC2-H82E8-sds
AC2-H82E8-elisa_1
AC2-H52H4 Human Human ACE2 / ACEH Protein, His Tag (MALS verified)
AC2-H52H4-sds
AC2-H52H4-elisa_1
AC2-H82E7 Human Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)
AC2-H82E7-structure
AC2-H82E7-sds
AC2-H82E7-elisa_1
AC2-H5255 Human Human ACE2 / ACEH Protein, Fc Tag (MALS verified)
AC2-H5255-sds
AC2-H5255-elisa_1
AC2-H5205 Human Human ACE2 / ACEH Protein, Mouse IgG1 Fc Tag (MALS verified)
AC2-H5205-structure
AC2-H5205-sds
AC2-H5205-elisa_1
MBS-K013 - Human ACE2-coupled Magnetic Beads
MBS-K013-elisa_1
AC2-P5248 Paguma larvata Paguma larvata ACE2 / ACEH Protein, His Tag (SPR verified)
AC2-P5248-structure
AC2-P5248-sds
AC2-P5248-elisa_1
AC2-P5248-elisa_2
AC2-M5248 Mouse Mouse ACE2 / ACEH Protein, His Tag (MALS verified)
AC2-M5248-structure
AC2-M5248-sds
AC2-R5246 Rat Rat ACE2 / ACEH Protein, His Tag (MALS verified)
AC2-R5246-structure
AC2-R5246-sds
AC2-C52H7 Cynomolgus Cynomolgus ACE2 / ACEH Protein, His Tag
AC2-C52H7-structure
AC2-C52H7-sds
AC2-C52H7-elisa_1
AC2-H5257 Human Human ACE2 / ACEH Protein, Fc Tag (MALS verified)
AC2-H5257-structure
AC2-H5257-sds
AC2-H5257-elisa_1
AC2-H5257-elisa_2
AC2-H52H8 Human Human ACE2 / ACEH Protein, His Tag (MALS verified)
AC2-H52H8-structure
AC2-H52H8-sds
AC2-H52H8-elisa_1
AC2-H52H8-elisa_2
AC2-H82E6 Human Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)
AC2-H82E6-structure
AC2-H82E6-sds
AC2-H82E6-elisa_1
AC2-H82E6-elisa_2
AC2-H82F9 Human Biotinylated Human ACE2 / ACEH Protein, Fc,Avitag™
AC2-H82F9-structure
AC2-H82F9-sds

Part of Bioactivity data

CHEK-ATP042-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

Flow Cytometry assay shows that SARS-CoV-2 S1 protein, Mouse IgG2a Fc Tag (Cat. No. S1N-C5257) can bind to HEK293/Human ACE2 Overexpression Stable Cell Line (Cat. No. CHEK-ATP042). The concentration of S1 used is 20 μg/mL (QC tested).

AC2-P5248-SPR
Human_FcRn_Heterodimer_Protein_SPR

Paguma larvata ACE2, His Tag (Cat. No. AC2-P5248) immobilized on CM5 Chip can bind SARS S protein RBD, His Tag (Cat. No. SPD-S52H6) with an affinity constant of 0.101 μM as determined in a SPR assay (Biacore T200) (QC tested).

AC2-P5248-SPR
Human_FcRn_Heterodimer_Protein_SPR

Paguma larvata ACE2, His Tag (Cat. No. AC2-P5248) immobilized on CM5 Chip can bind SARS-CoV-2 S protein RBD, His Tag (Cat. No. SPD-C52H3) with an affinity constant of 29 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

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Synonym Name

ACE-2,ACEH,ACE2

Background

Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.

Clinical and Translational Updates

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