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ACE2

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ACE2 Part of Bioactivity data

AC2-P5248-SPR
Human_FcRn_Heterodimer_Protein_SPR

Paguma larvata ACE2, His Tag (Cat. No. AC2-P5248) immobilized on CM5 Chip can bind SARS S protein RBD, His Tag (Cat. No. SPD-S52H6) with an affinity constant of 0.101 μM as determined in a SPR assay (Biacore T200) (QC tested).

AC2-P5248-SPR
Human_FcRn_Heterodimer_Protein_SPR

Paguma larvata ACE2, His Tag (Cat. No. AC2-P5248) immobilized on CM5 Chip can bind SARS-CoV-2 S protein RBD, His Tag (Cat. No. SPD-C52H3) with an affinity constant of 29 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

ACE2 Molecule Synonym Name

ACE-2,ACEH,ACE2

ACE2 Molecule Background

Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.

ACE2 References

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