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Flow cytometric analysis of Jurkat staining with Anti-Human CD5 Antibody, Mouse IgG1 (2C8A7) (Cat. No. FABm032-01) FACS Protocol at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 1e6 cells in a final volume of 100 µL), compared with isotype control antibody. PE signal was used to evaluate the binding activity (QC tested).
1e5 of Mouse Anti-CD5 antibody coupled beads (5.5 μm) were stained with different concentration of Alexa Fluor 488-Labeled Human CD5 Protein, His Tag (Cat. No. CD5-HA2H6) and negative control protein respectively, AF488 signal was used to evaluate the binding activity (QC tested).
Immobilized Alexa Fluor 488-Labeled Human CD5 Protein, Fc Tag (Cat. No. CD5-HA253) at 1 μg/mL (100 μL/well) can bind Mouse Anti-CD5 Antibody, Mouse IgG1 with a linear range of 0.1-4 ng/mL (Routinely tested). Labeling with fluorescent dyes did not affect their activity.
The purity of Rhesus macaque CD5 Protein, His Tag (Cat. No. CD5-R52H3) is more than 90% and the molecular weight of this protein is around 85-105 kDa verified by SEC-MALS.
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| CD5/CD7-Specific CAR-T Cells therapy(Essen Biotech) | BAH246; BAH-246; EB-BH2026 | Phase 2 Clinical | Essen Biotech | Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Prolymphocytic, T-Cell; Lymphoma, T-Cell; Central Nervous System Diseases; Leukemia, T-Cell | Details |
| CD5 CAR T Cells therapy(Beijing GoBroad Hospital) | Phase 2 Clinical | Beijing GoBroad Hospital | Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Details | |
| MB-105(March Biosciences) | MB-105(March Biosciences) | Phase 2 Clinical | March Biosciences Inc | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Mantle-Cell; Lymphoma, T-Cell; Leukemia, Lymphocytic, Chronic, B-Cell | Details |
| anti-CD5 CAR T-cell therapy (Beijing Boren Hospital) | Phase 1 Clinical | Beijing Gao Boren Hospital Co Ltd | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Details | |
| CD5CAR | CD5CAR | Phase 1 Clinical | iCell Gene Therapeutics LLC | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin | Details |
| CT-125A | CT-125A; RD-125 | Phase 1 Clinical | Nanjing Iaso Biotherapeutics Co Ltd | Hematologic Neoplasms; Lymphoma, T-Cell, Peripheral; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Plasmablastic Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, T-Cell; Leukemia, Lymphocytic, Chronic, B-Cell | Details |
| CD5 CAR T-cells therapy(Yake Biotechnology) | Phase 1 Clinical | Shanghai YaKe Biotechnology Co Ltd | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Details | |
| AB-205 (Artiva Biotherapeutics/GC Cell) | CD5 CAR-NK; GCC-2005; GL-205; GCC2005 | Phase 1 Clinical | GC Cell Corp | Lymphoma, T-Cell | Details |
| CD5 CAR T-Cells (Baylor College of Medicine) | Phase 1 Clinical | Baylor College Of Medicine | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Non-Hodgkin | Details | |
| CD5 CAR-T Therapy(Xuanwu Hospital) | Phase 1 Clinical | Xuanwu Hospital Of Capital Medical University | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Details |
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