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CD5

CD5 Molecule Information

Name:T-cell surface glycoprotein CD5
Target Synonym:T-cell surface glycoprotein CD5;Lymphocyte antigen T1/Leu-1;CD5;CD_antigen=CD5;LEU1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
CD5-H52H5 Human Human CD5 Protein, His Tag
CD5-H52H5-structure
CD5-H52H5-sds

CD5 Molecule Synonym Name

CD5,LEU1

CD5 Molecule Background

T-cell surface glycoprotein CD5 is also known as Lymphocyte antigen T1/Leu-1 and LEU1,which is phosphorylated on tyrosine residues by LYN,so CD5 can create binding sites for PTPN6/SHP-1.CD5 may act as a receptor in regulating T-cell proliferation. CD5 is expressed at various developmental and activation stages on human B cells.CD5 is a well established negative regulator of TCR and BCR signalling.CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. Development,selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.

CD5 References

CD5 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Monoclonal antibody T101-Y-90 conjugate Phase Ⅰ Nonindustrial source, Hybritech Incorporated hematological malignancies Details
Zolimomab aritox Phase Ⅲ Cancer Research UK, Xoma, Ortho-McNeil Diabetes, Graft versus host disease, Rheumatoid arthritis (RA), Rejection of renal transplantation Details

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