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Your Position: Home > IL-31

IL-31

IL-31 Protein Product ListCompare or Buy

Product> Filter Results

Cat. No.	Species	Product Description	Structure	Purity	Feature
IL1-C5245	Cynomolgus	Cynomolgus IL-31 Protein, His Tag
IL1-H5247	Human	Human IL-31 Protein, His Tag (MALS verified)

IL-31 Part of Bioactivity data

IL1-H5247-MALS-HPLC

Human IL-31, His TagHuman IL-31, His Tag (Cat. No. IL1-H5247) ELISA bioactivity

Immobilized Human IL-31, His Tag (Cat. No. IL1-H5247) at 1 μg/mL (100 μL/well) can bind Human IL-31 RA, Fc Tag (Cat. No. ILA-H5256) with a linear range of 0.02-0.625 μg/mL (QC tested).

Protocol

IL-31 Molecule Synonym Name

IL-31,IL31,Interleukin-31

IL-31 Molecule Background

IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor ? (OSMR?) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.