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CD58

Brief Information

Name:Lymphocyte function-associated antigen 3
Target Synonym:CD58 Antigens,Surface glycoprotein LFA-3,LFA3,LFA-3,CD58 Molecule,CD58 Antigen,CD58,CD58 Antigen, (Lymphocyte Function-Associated Antigen 3)
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Clinical

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By Product Status:
By Product Category:
By Species:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
LF3-H5256 Human Human CD58 / LFA-3 Protein, Fc Tag
LF3-H5256-structure
LF3-H5256-sds
LF3-H5256-elisa_1
LF3-H5225 Human Human CD58 / LFA-3 Protein, His Tag
LF3-H5225-structure
LF3-H5225-sds
LF3-H5225-elisa_1

Part of Bioactivity data

LF3-H5256-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded bind Human CD58, Fc Tag (Cat. No. LF3-H5256) on Protein A Biosensor, can bind Human CD2, His Tag (Cat. No. CD2-H5226) with an affinity constant of 8.42 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

LF3-H5225-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human CD2, Fc Tag (Cat. No. CD2-H5258) on Protein A Biosensor, can bind Human CD58, His Tag (Cat. No. LF3-H5225) with an affinity constant of 2.3 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

CD58,LFA3,Ag3

Background

CD antigen CD58 is also known as Lymphocyte function-associated antigen 3 (LFA-3). CD58 is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages. CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2) [3] on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant human LFA-3-antibody fusion protein (Taizhou Mabtech Pharmaceutical) Clinical Taizhou Maibo Taike Biotechnology Co Ltd Psoriasis Details

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