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NSP1

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Cat. No. Species Product Description Structure Purity Feature
NS1-C51H7 SARS-CoV-2 SARS-CoV-2 (COVID-19) NSP1 Protein, His Tag
NS1-C51H7-structure
NS1-C51H7-sds
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Synonym Name

NSP1,nsp1,Leader protein,Host translation inhibitor nsp1

Background

The viral nonstructural protein 1 (nsP1) is the only membrane-associated protein that anchors the replication complex to the cellular membranes. NSP1 inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.

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