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NSP1

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Cat. No. Species Product Description Structure Purity Feature
NS1-C51H7 SARS-CoV-2 SARS-CoV-2 (COVID-19) NSP1 Protein, His Tag
NS1-C51H7-structure
NS1-C51H7-sds

NSP1 Molecule Synonym Name

NSP1,nsp1,Leader protein,Host translation inhibitor nsp1

NSP1 Molecule Background

The viral nonstructural protein 1 (nsP1) is the only membrane-associated protein that anchors the replication complex to the cellular membranes. NSP1 inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.

NSP1 References

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