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Frizzled-10

Brief Information

Name:Frizzled-10
Target Synonym:FZD10,Frizzled 10, Seven Transmembrane Spanning Receptor,Frizzled Family Receptor 10,HFz10,FzE7,Frizzled (Drosophila) Homolog 10,Frizzled Homolog 10 (Drosophila),Frizzled Homolog 10,CD350 Antigen,Frizzled-10,CD350,Fz-10,Fz10,Frizzled Class Receptor 10
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

Synonym Name

Fz-10, FZD10, hFz10, FzE7, CD350

Background

Frizzled-10 (FZD10) is also known as FzE7 or CD350, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD10 contains one FZ (frizzled) domain. FZD10 protein is a cell surface receptor, which is activated by Wnt proteins and involved in the regulation of cellular function. FZD10 interacts with WNT7B and MYOC.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Yttrium 90-radiolabelled OTSA 101 DTPA-90Y; OTSA-101 Phase 1 Clinical Oncotherapy Science Sarcoma Details
Yttrium 90-radiolabelled OTSA 101 DTPA-90Y; OTSA-101 Phase 1 Clinical Oncotherapy Science Sarcoma Details

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