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Your Position: Home > NKG2C

NKG2C

Brief Information

Name:NKG2-C type II integral membrane protein
Target Synonym:Killer Cell Lectin Like Receptor C2,NKG2C,NKG2-C,CD159c,Killer Cell Lectin-Like Receptor Subfamily C, Member 2,CD159 Antigen-Like Family Member C,Natural Killer Cell Receptor G2-C,NKG2-C-Activating NK Receptor,NK Cell Receptor C,CD159c Antigen
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Cat. No. Species Product Description Structure Purity Feature
NKC-C5247 Cynomolgus Cynomolgus NKG2C / CD159c Protein, His Tag
NKC-C5247-structure
NKC-C5247-sds
NKC-H5248 Human Human NKG2C / CD159c Protein, His Tag
NKC-H5248-structure
NKC-H5248-sds
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Synonym Name

NKG2C,NKG2-C,CD159c,KLRC2,NK cell receptor C

Background

Human NKG2C (NK cell Group 2 isoform C; Killer cell lectin-like receptor subfamily C, member 2) is a member of the C-type lectin-like superfamily of proteins. NKG2C plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. The CD94/NKG2C killer lectin-like receptor (KLR) specific for HLA-E is coupled to the KARAP/DAP12 adapter in a subset of NK cells, triggering their effector functions. CD94/NKG2C may operate as an alternative activation pathway for a subset of CD8+ T lymphocytes, triggering their effector functions and proliferation upon specific ligand engagement.

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