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NOTCH2

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Cat. No. Species Product Description Structure Purity Feature
NO2-H5255 Human Human NOTCH2 Protein, Fc Tag
NO2-H5255-structure

NOTCH2 Molecule Synonym Name

NOTCH2, hN2, N2ECD

NOTCH2 Molecule Background

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation . Positively regulates self-renewal of liver cancer cells .

NOTCH2 References

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