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NOTCH2

Brief Information

Name:Neurogenic locus notch homolog protein 2
Target Synonym:N2ECD,NOTCH2,N2ICD,Notch 2,hN2,Neurogenic Locus Notch Homolog Protein 2,Notch (Drosophila) Homolog 2,Notch Homolog 2 (Drosophila),Notch Homolog 2,HJCYS,AGS2,Receptor, Notch2,Notch Receptor 2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
NO2-H5255 Human Human NOTCH2 Protein, Fc Tag (MALS verified)
NO2-H5255-structure
NO2-H5255-sds
NO2-H5255-elisa_1

Part of Bioactivity data

NO2-H5255-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human NOTCH2, Fc Tag (Cat. No. NO2-H5255) on Protein A Biosensor, can bind Human DLL4, His Tag (Cat. No. DL4-H5227) with an affinity constant of 77.6 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

NO2-H5255-MALS-HPLC
Human NOTCH2, Fc Tag (Cat. No. ) MALS images

The purity of Human NOTCH2, Fc Tag(Cat. No. NO2-H5255) was more than 85% and the molecular weight of this protein is around 175-190 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human NOTCH2, Fc TagHuman NOTCH2, Fc Tag (Cat. No. NO2-H5255) ELISA bioactivity

Immobilized Human DLL4, His Tag (Cat. No. DL4-H5227) at 5 μg/mL (100 μL/well) can bind Human NOTCH2, Fc Tag (Cat. No. NO2-H5255) with a linear range of 5-78 ng/mL (QC tested).

Synonym Name

NOTCH2, hN2, N2ECD

Background

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation . Positively regulates self-renewal of liver cancer cells .

Clinical and Translational Updates

    Clinical Drug Information

    Name Research Code Research Phase Company Indications Clinical Trials
    Tarextumab OMP-59R5 Phase 2 Clinical Oncomed Pharmaceuticals Solid tumours; Pancreatic Neoplasms; Small Cell Lung Carcinoma Details

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