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ASGR1

Brief Information

Name:Asialoglycoprotein receptor 1
Target Synonym:HL-1,Hepatic lectin H1,ASGPR 1,ASGR1,Asialoglycoprotein Receptor 1,CLEC4H1,ASGP-R 1,ASGPR1,ASGPR,C-type lectin domain family 4 member H1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
AS1-H5253 Human Human ASGR1 / ASGPR1 Protein, Fc Tag (MALS verified)
AS1-H5253-structure
AS1-H5253-sds

Part of Bioactivity data

AS1-H5253-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human ASGR1, Fc Tag (Cat. No. AS1-H5253) on Protein A Biosensor, can bind SARS-CoV-2 S1 protein NTD, His Tag (Cat. No. S1D-C52H6) with an affinity constant of 401 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

AS1-H5253-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human ASGR1, Fc Tag (Cat. No. AS1-H5253) on Protein A Biosensor, can bind SARS-CoV-2 S1 protein with an affinity constant of 4.09 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

ASGP-R 1, ASGPR 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1

Background

ASGPR, a transmembrane C-type lectin, recognizes a wide variety of ligands that contain either terminal galactose (Gal) or N-acetylgalactosamine (GalNAc) residues and has been identified as a highly selective receptor on hepatocytes. The ASGR is composed of both a major (ASGR1) and minor subunit (ASGR2). ASGR1 has been shown to be efficiently targeted to the plasma membrane and to undergo constitutive endocytosis and recycling and found mainly expressed in the human liver.

Clinical and Translational Updates

    Clinical Drug Information

    Name Research Code Research Phase Company Indications Clinical Trials
    AMG-529 AMG529; AMG-529 Phase 1 Clinical Amgen Inc Cardiovascular Diseases Details

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