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Your Position: Home > ASGR1

ASGR1

Brief Information

Name:Asialoglycoprotein receptor 1
Target Synonym:C-type lectin domain family 4 member H1,HL-1,Hepatic lectin H1,ASGPR 1,ASGR1,Asialoglycoprotein Receptor 1,CLEC4H1,ASGP-R 1,ASGPR1,ASGPR
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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By Product Status:
By Product Category:
By Species:
Cat. No. Species Product Description Structure Purity Feature
GS1-H82Q3 Human Biotinylated Human ASGR1 / ASGPR1, His,Avitag™
GS1-H82Q3-structure
GS1-H82Q3-sds
AS1-H5253 Human Human ASGR1 / ASGPR1 Protein, Fc Tag (MALS verified)
AS1-H5253-structure
AS1-H5253-sds

Part of Bioactivity data

GS1-H82Q3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human ASGR1 / ASGPR1, His,Avitag (Cat. No. GS1-H82Q3) on SA Biosensor, can bind SARS-CoV-2 , S1 protein, His tag (Cat. No. S1N-C52H4) with an affinity constant of 79.2 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

AS1-H5253-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human ASGR1, Fc Tag (Cat. No. AS1-H5253) on Protein A Biosensor, can bind SARS-CoV-2 S1 protein NTD, His Tag (Cat. No. S1D-C52H6) with an affinity constant of 401 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

ASGP-R 1, ASGPR 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1

Background

ASGPR, a transmembrane C-type lectin, recognizes a wide variety of ligands that contain either terminal galactose (Gal) or N-acetylgalactosamine (GalNAc) residues and has been identified as a highly selective receptor on hepatocytes. The ASGR is composed of both a major (ASGR1) and minor subunit (ASGR2). ASGR1 has been shown to be efficiently targeted to the plasma membrane and to undergo constitutive endocytosis and recycling and found mainly expressed in the human liver.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AMG-529 AMG529; AMG-529 Phase 1 Clinical Amgen Inc Cardiovascular Diseases Details

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