Loaded Human KREMEN1, Fc Tag (Cat. No. KR1-H5253) on Protein A Biosensor, can bind SARS-CoV-2 S protein RBD, His Tag (Cat. No. SPD-C52H3) with an affinity constant of 283 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Loaded Human KREMEN1, Fc Tag (Cat. No. KR1-H5253) on Protein A Biosensor, can bind SARS-CoV-2 S1 protein with an affinity constant of 114 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
KREMEN, KRM1,Dickkopf receptor/Kringle domain-containing transmembrane protein 1/Kringle-containing protein marking the eye and the nose
Kremens are high-affinity receptors for Dickkopf 1 (Dkk1) and regulate the Wnt/β-catenin signaling pathway by down-regulating the low-density lipoprotein receptor-related protein 6 (LRP6). Kremen1 is considered as one component of a membrane complex modulating canonical Wnt signalling through LRP6 in vertebrates. Additionally, KREMEN1 (KRM1) has also been identified as a functional receptor for Coxsackievirus A10 (CV-A10), a causative agent of hand-foot-and-mouth disease (HFMD).
Clinical and Translational Updates
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