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Brief Information

Name:Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Target Synonym:EC:,E-NPP 3,PD-Ibeta,NPPase,CD203c,PDNP3,Phosphodiesterase I/nucleotide pyrophosphatase 3,Nucleotide diphosphatase,ENPP3,DJ914N13.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3),Phosphodiesterase-I Beta,Phosphodiesterase I Beta,CD203c Antigen,Gp130RB13-6,NPP3,B10,Ectonucleotide pyrophosphatase/phosphodiesterase family member 3,Ectonucleotide Pyrophosphatase/Phosphodiesterase 3,DJ1005H11.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3),EC:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

CHEK-ATP122-Cell-based assay

Expression analysis of human ENPP3 on HEK293/Human ENPP3 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human ENPP3 Stable Cell Line or negative control cell using PE-labeled anti-human ENPP3 antibody.

ENPP3 MALS images

The purity of Mouse ENPP3 Protein, Fc Tag (Cat. No. EN3-M5263) is more than 90% and the molecular weight of this protein is around 245-285 kDa verified by SEC-MALS.

ENPP3 MALS images

The purity of Human ENPP3 Protein, Fc Tag (Cat. No. EN3-H5267) is more than 90% and the molecular weight of this protein is around 265-315 kDa verified by SEC-MALS.

Synonym Name



The human NPP family contains seven members which can be classified into two groups according to their substrate preferences. The first class comprises the nucleotide-degrading proteins NPP1, 3 and 4. NPP3 (CD203c, ENPP3) is expressed in multiple organs, including on epithelial and mucosal surfaces, and notably on basophils and mast cells. Activation of basophils by antigen-bound IgE leads to release of inflammatory mediators and rapid upregulation of NPP3 to the cell surface. This protein is in fact a common marker for diagnosing allergen sensitivity with patient basophils by flow cytometry. Basophils and mast cells mediate the response to certain pathogens, as well as acute and chronic allergic reactions. Following activation, these cells release ATP, which further stimulates them in an autocrine manner. NPP3 upregulation serves to degrade ATP and suppress chronic allergic inflammation (but not the acute response).

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AGS-16C3F AGS-16F; AGS-16C3F; AGS-16M8F Phase 2 Clinical Agensys Inc Carcinoma, Renal Cell Details
XmAb-819 XmAb-819 Phase 1 Clinical Xencor Inc Kidney Neoplasms; Carcinoma, Renal Cell Details
JNJ-87890387 JNJ-87890387 Phase 1 Clinical Janssen Research & Development Llc Solid tumours Details

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