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LGR4

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Cat. No. Species Product Description Structure Purity Feature
LG4-H52H3 Human Human LGR4 / GPR48 protein, His Tag
LG4-H52H3-structure
LG4-H52H3-sds
LG4-H52H3-elisa_1
LG4-H52H3-elisa_2

Part of Bioactivity data

LG4-H52H3-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human R-Spondin 3 immobilized on CM5 Chip can bind Human LGR4, His Tag (Cat. No. LG4-H52H3) with an affinity constant of 0.394 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

LG4-H52H3-ELISA
Human LGR4, His TagHuman LGR4, His Tag (Cat. No. LG4-H52H3) ELISA bioactivity

Immobilized Human R‑Spondin 3 at 2 μg/mL (100 μL/well) can bind Human LGR4, His Tag (Cat. No. LG4-H52H3) with a linear range of 10-78 ng/mL (QC tested).

Synonym Name

LGR4, GPR48, G-protein coupled receptor 48, Leucine-rich repeat-containing G-protein coupled receptor 4

Background

The fourth member of the leucine-rich repeat-containing GPCR family (LGR4, frequently referred to as GPR48) together with its family members LGR5 and -6, bind to R-spondins (RSPOs)-1–4 and result in Wnt signaling potentiation. In addition, LGR4 (as well as LGR5 and -6) is implicated in multiple cancers and promotes invasion and metastasis in colorectal, prostate, and cervical cancer cell lines.

Clinical and Translational Updates

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