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ZNRF3

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Cat. No. Species Product Description Structure Purity Feature
ZN3-H52H3 Human Human ZNRF3 protein, His Tag (MALS verified)
ZN3-H52H3-structure
ZN3-H52H3-sds

Part of Bioactivity data

ZN3-H52H3-ELISA
Human ZNRF3, His Tag (Cat. No. ) MALS images

The purity of Human ZNRF3, His Tag (Cat. No. ZN3-H52H3) was more than 90% and the molecular weight of this protein is around 18-27 kDa verified by SEC-MALS.

Report
  • Background
    The transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) is a negative feedback regulator of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6 and acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway.
  • Clinical and Translational Updates
      

  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Synonym Name

ZNRF3,  Zinc/RING finger protein 3, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, RNF203

Background

The transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) is a negative feedback regulator of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6 and acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway.

Clinical and Translational Updates

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