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CD45

Brief Information

Name:Leukocyte common antigen
Target Synonym:EC:3.1.3.48,PTPRC,T200,CD45,Protein Tyrosine Phosphatase, Receptor Type C,CD45 Antigen,L-CA,Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide,Receptor-Type Tyrosine-Protein Phosphatase C,T200 Leukocyte Common Antigen,Leukocyte Common Antigen,T200
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CD5-H52H8 Human Human CD45 / PTPRC protein, His Tag
CD5-H52H8-structure
CD5-H52H8-sds
CD5-H82E7 Human Biotinylated Human CD45 / PTPRC protein, His,Avitag™ (MALS verified)
CD5-H82E7-structure
CD5-H82E7-sds

Part of Bioactivity data

CD5-H82E7-ELISA
Biotinylated Human CD45, His,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human CD45, His,Avitag (Cat. No. CD5-H82E7) was more than 85% and the molecular weight of this protein is around 180-210 kDa verified by SEC-MALS.

  • Background
    CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen. CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Synonym Name

CD45,PTPRC,L-CA,T200

Background

CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen. CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Immunomodulatory progenitor cell therapy (Celixir) Phase 3 Clinical Celixir Endomyocardial Fibrosis; Cardiomyopathies Details
I-131-Apamistamab BC8-I-131; BC-8 Phase 3 Clinical Fred Hutchinson Cancer Research Center Hematopoietic stem cell transplantation (HSCT); Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
At 211 MAb BC8-B10 Phase 2 Clinical Fred Hutchinson Cancer Research Center Neoplasms Details

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