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Your Position: Home > CD45

CD45

Brief Information

Name:Leukocyte common antigen
Target Synonym:PTPRC,T200,CD45,Protein Tyrosine Phosphatase, Receptor Type C,CD45 Antigen,L-CA,Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide,Receptor-Type Tyrosine-Protein Phosphatase C,T200 Leukocyte Common Antigen,Leukocyte Common Antigen,T200 Glycoprotein,EC 3.1.3.48,CD45R,GP180,B220,LCA,LY5,Leukocyte Common Antigens,Protein Tyrosine Phosphatase Receptor Type C,EC:3.1.3.48
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

The purity of Biotinylated Human CD45, His,Avitag (Cat. No. CD5-H82E7) is more than 85% and the molecular weight of this protein is around 180-210 kDa verified by SEC-MALS.

  • Background
    CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen. CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Customer Reviews

Synonym Name

CD45,PTPRC,L-CA,T200

Background

CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen. CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
At 211 MAb BC8-B10 Phase 2 Clinical Fred Hutchinson Cancer Research Center Neoplasms Details
Immunomodulatory progenitor cell therapy (Celixir) Phase 3 Clinical Celixir Cardiomyopathies Details
I-131-Apamistamab BC8-I-131; BC-8 Phase 3 Clinical Fred Hutchinson Cancer Research Center Lymphoma, B-Cell; Hematopoietic stem cell transplantation (HSCT); Lymphoma, Large B-Cell, Diffuse; Fanconi Anemia; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Burkitt Lymphoma; Leukemia, Myeloid, Acute Details

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