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Your Position: Home > GDF-8

GDF-8

Brief Information

Name:Growth/differentiation factor 8
Target Synonym:MSTN,GDF-8,GDF8,Growth Differentiation Factor 8,MSLHP,Myostatin,Growth/Differentiation Factor 8
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 3 Clinical

Synonym Name

GDF-8, Myostatin, GDF8, MSTN, Growth/differentiation factor 8

Background

Growth differentiation factor 8 (GDF8), also known as myostatin, is a unique member of the transforming growth factor-β superfamily that is expressed in human granulosa cells and has important roles in regulating a variety of ovarian functions. GDF8 acts as a negative regulator of skeletal muscle growth and differentiation. In addition to the expression in the musculoskeletal system, GDF8 is also expressed in various tissues, including the reproductive system.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Domagrozumab PF-6252616; PF-06252616 Phase 2 Clinical Pfizer Inc Muscular Dystrophy, Duchenne Details
AAV1-FS344 AAV1-FS344; AAV1-Follistatin Phase 2 Clinical Nationwide Children'S Hospital Myositis, Inclusion Body; Muscular Dystrophy, Duchenne Details
Trevogrumab REGN-1033; SAR-391786 Phase 2 Clinical Regeneron Pharmaceuticals Inc Myositis, Inclusion Body; Muscular Atrophy; Sarcopenia Details
Talditercept alfa (Bristol-Myers Squibb) RO-7239361; BMS-986089; RG-6206 Phase 3 Clinical Bristol-Myers Squibb Company Muscular Dystrophy, Duchenne Details
RG-6237 GYM-329; RG-70240; RG-6237 Phase 1 Clinical F. Hoffmann-La Roche Ltd, Chugai Pharmaceutical Co Ltd Neuromuscular Diseases Details
Apitegromab SRK-015 Phase 3 Clinical Scholar Rock Spinal Muscular Atrophies of Childhood; Neuromuscular Manifestations; Muscular Atrophy; Neuromuscular Diseases; Muscular Atrophy, Spinal; Atrophy Details

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