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KREMEN2

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Cat. No. Species Product Description Structure Purity Feature
KR2-H52H9 Human Human Kremen-2 CUB Domain, His Tag
KR2-H52H9-structure
KR2-H52H9-sds
KR2-H52H3 Human Human Kremen-2 protein, His Tag
KR2-H52H3-structure
KR2-H52H3-sds

Part of Bioactivity data

KR2-H52H3-ELISA
Human Kremen-2, His TagHuman Kremen-2, His Tag (Cat. No. KR2-H52H3) ELISA bioactivity

Immobilized Human Dkk-1, Fc Tag (Cat. No. DK1-H5258) at 2 μg/mL (100 μL/well) can bind Human Kremen-2, His Tag (Cat. No. KR2-H52H3) with a linear range of 10-78 ng/mL (QC tested).

Protocol

Synonym Name

KREMEN2, Kremen-2, KRM2, Dickkopf receptor 2,Kringle domain-containing transmembrane protein 2

Background

Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Krm1 and its paralog Krm2 share the ability to bind Dkk1 and inhibit Wnt signaling, both processes previously shown to rely on the extracellular domain. Previous studies have shown that Krm2 may be involved in embryonic development, bone formation, neural ridge formation and tumorigenesis and could be a biomarker of grading and a potential therapeutic target in gastric cancer.

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