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Spike protein

Brief Information

Name:Interleukin-17 receptor A
Target Synonym:IL-17 receptor A,IL17R,IL17RA,Interleukin 17 Receptor A,IL-17RA,Interleukin 17 Receptor,CD217 Antigen,HIL-17R,CANDF5,CD217,IMD51,CDw217,Interleukin-17 receptor A
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
SPN-C52Hb SARS-CoV-2 SARS-CoV-2 Spike Trimer (C136F, Y144del, R190S, D215G, LA242-243del, Y449H, E484K, N501Y, D614G, H655Y, N679K, T716I, T859N), His Tag (MALS verified)
SPN-C52Hb-sds
SPN-C52Hb-elisa_1
SPN-C82Ek SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer (T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, D950N), His,Avitag™ (MALS verified)
SPN-C82Ek-sds
SPN-C82Ek-elisa_1
SPN-C52Ha SARS-CoV-2 SARS-CoV-2 Spike Trimer (T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, D950N), His Tag (MALS verified)
SPN-C52Ha-sds
SPN-C52Ha-elisa_1
SPN-C82Eq SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer (C136F, Y144del, R190S, D215G, LA242-243del, Y449H, E484K, N501Y, D614G, H655Y, N679K, T716I, T859N), His,Avitag™ (MALS verified)
SPN-C82Eq-sds
SPN-C82Eq-elisa_1
RAS-A039 SARS-CoV-2 SARS-CoV-2 Spike Protein ELISA Kit (For Vaccine Development)
RAS-A039-elisa_1
SPN-C82Ei SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer (T19R, V70F, FR157-158Del, A222V, W258L, K417N, L452R, T478K, D614G, P681R, D950N), His,Avitag™ (MALS verified)
SPN-C82Ei-sds
SPN-C82Ei-elisa_1
SPN-C52Ht SARS-CoV-2 SARS-CoV-2 Spike Trimer (T19R, V70F, FR157-158Del, A222V, W258L, K417N, L452R, T478K, D614G, P681R, D950N), His Tag (MALS verified)
SPN-C52Ht-sds
SPN-C52Ht-elisa_1
SPN-C52Hv SARS-CoV-2 SARS-CoV-2 Spike Trimer (D614G), His Tag (MALS verified)
SPN-C52Hv-sds
SPN-C52Hv-elisa_1
SPN-CR2H7 SARS-CoV-2 HRP-SARS-CoV-2 Spike Trimer (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N), His Tag
SPN-CR2H7-elisa_1
SPN-CR2H3 SARS-CoV-2 HRP-SARS-CoV-2 Spike Trimer (D614G), His Tag
SPN-CR2H3-elisa_1
RAS-T025 SARS-CoV-2 Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
RAS-T025-elisa_1
SPN-C52Hs SARS-CoV-2 SARS-CoV-2 Spike Trimer (G75V, T76I, SYLTPGD 247-253 del, L452Q, F490S, D614G, T859N), His Tag (MALS verified)
SPN-C52Hs-sds
SPN-C52Hs-elisa_1
SPN-C82Eh SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer (G75V, T76I, SYLTPGD 247-253 del, L452Q, F490S, D614G, T859N), His,Avitag™ (MALS verified)
SPN-C82Eh-sds
SPN-C82Eh-elisa_1
MBS-K038 SARS-CoV-2 SARS-CoV-2 (Delta) Spike Trimer-coupled Magnetic Beads
MBS-K038-elisa_1
SPN-C52Hm SARS-CoV-2 SARS-CoV-2 Spike Trimer (K417N, D614G), His Tag (MALS verified)
SPN-C52Hm-sds
SPN-C52Hm-elisa_1
SPN-C52Hq SARS-CoV-2 SARS-CoV-2 Spike Trimer (E484K, D614G), His Tag (MALS verified)
SPN-C52Hq-sds
SPN-C52Hq-elisa_1
SPN-C52Hp SARS-CoV-2 SARS-CoV-2 Spike Trimer (N501Y, D614G), His Tag (MALS verified)
SPN-C52Hp-sds
SPN-C52Hp-elisa_1
SPN-C52Hn SARS-CoV-2 SARS-CoV-2 Spike Trimer (K417T, D614G), His Tag (MALS verified)
SPN-C52Hn-sds
SPN-C52Hn-elisa_1
RAS-N041 SARS-CoV-2 Anti-SARS-CoV-2 (B.1.617.2) Neutralizing Antibody Titer Serologic Assay Kit (Spike Trimer)
SPN-C52Hh SARS-CoV-2 SARS-CoV-2 Spike Trimer (P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H, T1027I, D1118H), His Tag (MALS verified)
SPN-C52Hh-sds
SPN-C52Hh-elisa_1
SPN-C82Ed SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer (P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H, T1027I, D1118H), His,Avitag™ (MALS verified)
SPN-C82Ed-sds
SPN-C82Ed-elisa_1
SPN-C52He SARS-CoV-2 SARS-CoV-2 Spike Trimer (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N), His Tag (MALS verified)
SPN-C52He-sds
SPN-C52He-elisa_1
SPN-C82Ec SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N), His,Avitag™ (MALS verified)
SPN-C82Ec-sds
SPN-C82Ec-elisa_1
RAS-T023 SARS-CoV-2 Mouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
RAS-T023-elisa_1
SPN-C52Hr SARS-CoV-2 SARS-CoV-2 Spike Trimer (T95I, G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H), His Tag (MALS verified)
SPN-C52Hr-sds
SPN-C52Hr-elisa_1
SPN-C82E7 SARS-CoV-2 Biotinylated SARS-CoV-2 Spike Trimer (T95I, G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H), His,Avitag™ (MALS verified)
SPN-C82E7-sds
SPN-C82E7-elisa_1
SPN-H82E3 HCoV-HKU1 Biotinylated HCoV-HKU1 (isolate N5) Spike Trimer, His,Avitag™ (MALS verified)
SPN-H82E3-structure
SPN-H82E3-sds
TAS-K025 SARS-CoV-2 Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
TAS-K025-elisa_1
SPN-H82E6 HCoV-NL63 Biotinylated HCoV-NL63 Spike protein, His,Avitag™
SPN-H82E6-structure
SPN-H82E6-sds
SPN-H52H5 HCoV-HKU1 HCoV-HKU1 (isolate N5) Spike Trimer, His Tag (MALS verified)
SPN-H52H5-structure
SPN-H52H5-sds
SPN-H52H4 HCoV-NL63 HCoV-NL63 S protein, His Tag
SPN-H52H4-structure
SPN-H52H4-sds
SPN-H52H3 HCoV-229E HCoV-229E Spike protein, His Tag
SPN-H52H3-structure
SPN-H52H3-sds
MBS-K029 SARS-CoV-2 SARS-CoV-2 Spike Trimer (B.1.1.7) Coupled Magnetic Beads
MBS-K029-elisa_1
MBS-K031 SARS-CoV-2 SARS-CoV-2 Spike Trimer (P.1) Coupled Magnetic Beads
MBS-K031-elisa_1
MBS-K030 SARS-CoV-2 SARS-CoV-2 Spike Trimer (B.1.351) Coupled Magnetic Beads
MBS-K030-elisa_1
RAS-T027 SARS-CoV-2 Anti-SARS-CoV-2 (B.1.1.7) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
RAS-T027-elisa_1
RAS-A020 SARS-CoV-2 SARS-CoV-2 Spike Protein Titer Assay Kit
RAS-A020-elisa_1
RAS-T033 SARS-CoV-2 Anti-SARS-CoV-2 (P.1) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
RAS-T033-elisa_1
RAS-T030 SARS-CoV-2 Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)
RAS-T030-elisa_1
SPN-M52H4 MERS MERS Spike protein trimer (R748A, R751A, V1060P, L1061P), His Tag (MALS verified)
SPN-M52H4-structure
SPN-M52H4-sds
SPN-M52H4-elisa_1
SPN-C52Hk SARS-CoV-2 SARS-CoV-2 S protein (L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V) trimer, His Tag (MALS verified)
SPN-C52Hk-sds
SPN-C52Hk-elisa_1
SPN-C52Hk-elisa_2
SPN-C82E5 SARS-CoV-2 Biotinylated SARS-CoV-2 S protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) trimer, His,Avitag™ (MALS verified)
SPN-C82E5-sds
SPN-C82E5-elisa_1
SPN-C82E4 SARS-CoV-2 Biotinylated SARS-CoV-2 S protein (L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V) trimer, His,Avitag™ (MALS verified)
SPN-C82E4-sds
SPN-C82E4-elisa_1
SPN-C82E6 SARS-CoV-2 Biotinylated SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F) trimer, His,Avitag™ (MALS verified)
SPN-C82E6-sds
SPN-C82E6-elisa_1
SPN-C52Hg SARS-CoV-2 SARS-CoV-2 S protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F), His Tag (MALS verified)
SPN-C52Hg-sds
SPN-C52Hg-elisa_1
SPN-C52Hg-elisa_2
SPN-C52Hd SARS-CoV-2 SARS-CoV-2 S protein (F817P, A892P, A899P, A942P, K986P, V987P), His Tag (MALS verified)
SPN-C52Hd-sds
SPN-C52Hd-elisa_1
SPN-S52H6 SARS SARS S protein (R667A, K968P, V969P), His Tag (MALS verified)
SPN-S52H6-structure
SPN-S52H6-sds
SPN-S52H6-elisa_1
SPN-C52H6 SARS-CoV-2 SARS-CoV-2 S protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H), His Tag (MALS verified)
SPN-C52H6-sds
SPN-C52H6-elisa_1
SPN-C52H6-elisa_2
SPN-C52H7 SARS-CoV-2 SARS-CoV-2 S protein, His Tag, Super stable trimer (MALS verified)
SPN-C52H7-sds
SPN-C52H7-elisa_1
MBS-K015 SARS-CoV-2 SARS-CoV-2 Spike Trimer-coupled Magnetic Beads
MBS-K015-elisa_1
MBS-K016 SARS-CoV-2 SARS-CoV-2 Spike Trimer (D614G)-coupled Magnetic Beads
MBS-K016-elisa_1
SPN-C82E3 SARS-CoV-2 Biotinylated SARS-CoV-2 S protein (D614G), His,Avitag™, Super stable trimer (MALS verified)
SPN-C82E3-sds
SPN-C82E3-elisa_1
SPN-C52H3 SARS-CoV-2 SARS-CoV-2 S protein (D614G), His Tag, Super stable trimer (MALS verified)
SPN-C52H3-sds
SPN-C52H3-elisa_1
SPN-C52H9 SARS-CoV-2 SARS-CoV-2 S protein, His Tag, Super stable trimer (MALS & NS-EM verified)
SPN-C52H9-sds
SPN-C52H9-elisa_1
SPN-C52H9-elisa_2
SPN-C82E9 SARS-CoV-2 Biotinylated SARS-CoV-2 S protein, His,Avitag™, Super stable trimer (MALS verified)
SPN-C82E9-sds
SPN-C82E9-elisa_1
EP-105 SARS-CoV-2 SARS-CoV-2 (COVID-19) Inhibitor screening Kit
EP-105-elisa_1

Part of Bioactivity data

SPN-C52Hk-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human ACE2, Fc Tag (Cat. No. AC2-H5257) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind SARS-CoV-2 S protein trimer, His Tag (Cat. No. SPN-C52Hk) with an affinity constant of 1.12 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

SPN-C52Hg-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human ACE2, Fc Tag (Cat. No. AC2-H5257) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind SARS-CoV-2 S protein, His Tag (Cat. No. SPN-C52Hg) with an affinity constant of 1.78 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Customer Reviews

Synonym Name

Spike,S protein,Spike glycoprotein,S glycoprotein

Background

The newly identified 2019 novel coronavirus (SARS-CoV-2) has posed a serious threat to human health. Currently, there is no specific treatment for COVID-19. It is urgent to develop the SARS-CoV-2 inhibitors, for example vaccines and therapeutic antibodies and small molecular compounds against COVID-19.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Brodalumab IL-17R mAb; MEDI-6365; KHK-4827; AMG-827 Approved Amgen Inc Siliq, Lumicef, Kyntheum, 立美芙 Mainland China Plaque psoriasis Kyowa Kirin 2016-07-04 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Scleroderma, Systemic; Psoriasis; Arthritis, Psoriatic; Asthma; Plaque psoriasis; Crohn Disease Details
Brodalumab IL-17R mAb; MEDI-6365; KHK-4827; AMG-827 Approved Amgen Inc Siliq, Lumicef, Kyntheum, 立美芙 Mainland China Plaque psoriasis Kyowa Kirin 2016-07-04 Spondylitis, Ankylosing; Arthritis, Rheumatoid; Scleroderma, Systemic; Psoriasis; Arthritis, Psoriatic; Asthma; Plaque psoriasis; Crohn Disease Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
XCUR-17 XCUR-17 Phase 1 Clinical Exicure Psoriasis Details
LY-3114062 LY3114062; LY-3114062 Phase 1 Clinical Eli Lilly And Company Arthritis Details
XCUR-17 XCUR-17 Phase 1 Clinical Exicure Psoriasis Details
LY-3114062 LY3114062; LY-3114062 Phase 1 Clinical Eli Lilly And Company Arthritis Details

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