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TLR2

Brief Information

Name:Toll like receptor 2
Target Synonym:CD282,Toll-like receptor 2,TIL4,Toll/interleukin-1 receptor-like protein 4,TLR2,Toll Like Receptor 2,CD282 Antigen,EC:3.2.2.6
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 2 Clinical

Synonym Name

Background

Toll-like receptors (TLRs) take key roles in the host immune response and are swiftly activated by infection or other types of immunological stress. Toll-like receptor 2 (TLR2) is indicated to initiate the activation of NLRP3 inflammasome and might involve in asthma. Additionally, further research uncovered that Wnt5a is also a direct ligand of toll-like receptor (TLR) 2 and 4 might affect the typical pattern recognition receptor-induced innate immune response genes.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
DMT-210 DMT-200; DMT-210; DMT-220; SIG-990 Phase 2 Clinical Signum Dermalogix Rosacea; Dermatitis, Atopic Details
VB-201 CI-201; VB-201 Phase 2 Clinical Vbl Atherosclerosis; Coronavirus Disease 2019 (COVID-19); Psoriasis; Colitis, Ulcerative Details
Tomaralimab (Opsona Therapeutics) OPN-305 Phase 2 Clinical Opsona Therapeutics Autoimmune Diseases; Myelodysplastic Syndromes; Delayed Graft Function; Inflammation Details
CBLB-612 CBLB-612 Phase 2 Clinical Cleveland Biolabs Hematopoietic stem cell transplantation (HSCT); Breast Neoplasms Details
TR-987 Z-101; GLYC-101; MG-3601 Phase 2 Clinical Kazia Therapeutics Wounds and Injuries; Varicose Ulcer Details

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