TLR2 Protein - ACROBiosystems

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TLR2

Brief Information

Name:Toll like receptor 2
Target Synonym:CD282,Toll-like receptor 2,TIL4,Toll/interleukin-1 receptor-like protein 4,TLR2,Toll Like Receptor 2,CD282 Antigen,EC:3.2.2.6

Number of Launched Drugs:1
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 2 Clinical

Synonym Name

Background

Toll-like receptors (TLRs) take key roles in the host immune response and are swiftly activated by infection or other types of immunological stress. Toll-like receptor 2 (TLR2) is indicated to initiate the activation of NLRP3 inflammasome and might involve in asthma. Additionally, further research uncovered that Wnt5a is also a direct ligand of toll-like receptor (TLR) 2 and 4 might affect the typical pattern recognition receptor-induced innate immune response genes.

Clinical and Translational Updates

Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
DMT-210	DMT-200; DMT-210; DMT-220; SIG-990	Phase 2 Clinical	Signum Dermalogix	Rosacea; Dermatitis, Atopic	Details
VB-201	CI-201; VB-201	Phase 2 Clinical	Vbl	Atherosclerosis; Coronavirus Disease 2019 (COVID-19); Psoriasis; Colitis, Ulcerative	Details
Tomaralimab (Opsona Therapeutics)	OPN-305	Phase 2 Clinical	Opsona Therapeutics	Autoimmune Diseases; Myelodysplastic Syndromes; Delayed Graft Function; Inflammation	Details
CBLB-612	CBLB-612	Phase 2 Clinical	Cleveland Biolabs	Hematopoietic stem cell transplantation (HSCT); Breast Neoplasms	Details
TR-987	Z-101; GLYC-101; MG-3601	Phase 2 Clinical	Kazia Therapeutics	Wounds and Injuries; Varicose Ulcer	Details