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Your Position: Home > GPRC5D

GPRC5D

Brief Information

Name:G-protein coupled receptor family C group 5member D
Target Synonym:G Protein-Coupled Receptor Class C Group 5 Member D,G-Protein Coupled Receptor Family C Group 5 Member D,G Protein-Coupled Receptor, Class C, Group 5, Member D,G Protein-Coupled Receptor, Family C, Group 5, Member D,GPRC5D,Orphan G-Protein Coupled Receptor
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

GPD-C52D3-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-GPRC5D antibody immobilized on CM5 Chip can bind Cynomolgus GPRC5D, Flag,His Tag (Cat. No. GPD-C52D3) with an affinity constant of 0.346 μM as determined in a SPR assay (Biacore 8K) (QC tested).

GPD-C82D4-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-GPRC5D antibody immobilized on CM5 Chip can bind Cynomolgus GPRC5D, Flag,His Tag (Nanodisc) (Cat. No. GPD-C82D4) with an affinity constant of 0.134 μM as determined in a SPR assay (Biacore 8K) (QC tested).

Synonym Name

GPRC5D

Background

G-protein coupled receptor family C group 5 member D (GPRC5D) is a retinoic acid-inducible 40 kDa protein with seven transmembrane segments and a short N terminal extracellular region. Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscle and ovary.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ori-CAR-017 Ori-CAR-017 Phase 1 Clinical Multiple Myeloma Details
MCARH-109 Phase 1 Clinical Memorial Sloan Kettering Cancer Center Multiple Myeloma Details
CAR-GPRC5D CAR-GPRC5D Phase 1 Clinical Nanjing Iaso Biotherapeutics Co Ltd Leukemia, Plasma Cell; Multiple Myeloma Details
Talquetamab JNJ-7564; JNJ-64407564 Phase 3 Clinical Janssen Global Services Llc, Genmab Hematologic Neoplasms; Multiple Myeloma Details
OriC-321 OriC-321; Ori-C-321 Phase 1 Clinical Zhejiang University, OriginCell Therapeutics Co Ltd Multiple Myeloma Details
LM-305 LM-305 Phase 1 Clinical LaNova Medicines Ltd Multiple Myeloma Details

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