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Your Position: Home > GPRC5D

GPRC5D

Brief Information

Name:G-protein coupled receptor family C group 5member D
Target Synonym:G Protein-Coupled Receptor Class C Group 5 Member D,G-Protein Coupled Receptor Family C Group 5 Member D,G Protein-Coupled Receptor, Class C, Group 5, Member D,G Protein-Coupled Receptor, Family C, Group 5, Member D,GPRC5D,Orphan G-Protein Coupled Receptor
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:17
Lastest Research Phase:Approved

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
GPRC5D VHH - 01 PCC Hematological Malignancy Multiple myeloma

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Part of Bioactivity data

CCHO-STP078-Cell-based assay
 GPRC5D FACS

FACS Analysis of CHO/Human GPRC5D Stable Cell Line.

FACS assay shows that Anti-GPRC5D antibody can bind to CHO/Human GPRC5D Stable Cell Line (Fig. B), and non-transfected CHO cells were used as a negative control (Fig. A). PE signal was used to evaluate the binding activity (QC tested).

GPD-HF2D7-SPR
 GPRC5D SPR

Anti-GPRC5D Antibody, Human IgG4 captured on Protein A Chip can bind FITC-Labeled Human GPRC5D Protein, Flag,His Tag (Cat. No. GPD-HF2D7) with an affinity constant of 9.29 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

GPD-C52D3-SPR
 GPRC5D SPR

Anti-GPRC5D Antibody immobilized on CM5 Chip can bind Cynomolgus GPRC5D, Flag,His Tag (Cat. No. GPD-C52D3) with an affinity constant of 0.122 μM as determined in a SPR assay (Biacore T200) (QC tested).

Synonym Name

GPRC5D

Background

G-protein coupled receptor family C group 5 member D (GPRC5D) is a retinoic acid-inducible 40 kDa protein with seven transmembrane segments and a short N terminal extracellular region. Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscle and ovary.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Talquetamab JNJ-64407564; JNJ-7564 Approved Genmab A/S, Janssen Global Services Llc TALVEY United States Multiple Myeloma Janssen Biotech Inc 2023-08-09 Hematologic Neoplasms; Multiple Myeloma Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Autologous anti-BCMA/GPRC5D CAR-T cell therapy (Xuzhou Medical University) Phase 2 Clinical Xuzhou Medical University (Xzmu) Multiple Myeloma Details
Anti-GPRC5D CAR-T Cells Therapy(Institute of Hematology & Blood Diseases Hospital) Institute Of Hematology & Blood Diseases Hospital Details
Forimtamig RG-6234 Phase 1 Clinical F. Hoffmann-La Roche Ltd Multiple Myeloma Details
RO-7425781 RO-7425781 Phase 1 Clinical F. Hoffmann-La Roche Ltd Multiple Myeloma Details
Anti-GPRC5D CAR-T Cells Therapy (Shanghai YaKe Biotechnology) Phase 2 Clinical Shanghai YaKe Biotechnology Co Ltd Multiple Myeloma Details
Anti-GPRC5D CAR-T Cells Therapy(920th Hospital) Phase 2 Clinical The 920th Hospital Of Joint Logistics Support Force Of PLA Multiple Myeloma Details
MCARH-109 Phase 1 Clinical Memorial Sloan Kettering Cancer Center, Juno Therapeutics Inc, Eureka Therapeutics Inc Multiple Myeloma Details
CT-071 CT071; CT-071 Phase 1 Clinical CARsgen Therapeutics Holdings Ltd Leukemia, Plasma Cell; Multiple Myeloma Details
CAR-GPRC5D CAR-GPRC5D Phase 1 Clinical Nanjing Iaso Biotherapeutics Co Ltd Leukemia, Plasma Cell; Multiple Myeloma Details
LM-305 LM-305 Phase 2 Clinical LaNova Medicines Ltd Multiple Myeloma Details
Ori-CAR-017 Ori-CAR-017; OriCAR-017 Phase 2 Clinical OriCell Therapeutics Co Ltd Multiple Myeloma Details
OriC-321 OriC-321; Ori-C-321 Phase 1 Clinical Zhejiang University, OriCell Therapeutics Co Ltd Multiple Myeloma Details
IBI-3003 IBI3003; IBI-3003 Phase 2 Clinical Innovent Biologics(Suzhou) Co Ltd Multiple Myeloma Details
BCMA-GPRC5D CAR-T Cells Therapy(Wuhan Union Hospital) Phase 2 Clinical Guangzhou Bio-Gene Technology Co Ltd, Wuhan Union Hospital Multiple Myeloma Details
MBS-314 MBS-314 Phase 1 Clinical Beijing Mabworks Biotech Co Ltd Multiple Myeloma Details
BCMAxGPRC5D CAR-T therapy(Juno Therapeutics) BMS-986453 Phase 1 Clinical Juno Therapeutics Inc Multiple Myeloma Details
LBL-034 LBL-034 Phase 2 Clinical Nanjing Leads Biolabs Co Ltd Neoplasms; Multiple Myeloma Details
CC-95266 BMS986393; BMS-986393; CC-95266 Phase 1 Clinical Juno Therapeutics Inc Multiple Myeloma Details

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