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Your Position: Home > TLR8

TLR8

Brief Information

Name:Toll like receptor 8
Target Synonym:UNQ249/PRO286,TLR8,Toll-like receptor 8,CD288,Toll Like Receptor 8,CD288 Antigen
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Phase 2 Clinical

Synonym Name

TLR8/CD288/Toll-like receptor 8

Background

Toll-like receptors (TLRs) sense pathogen-associated molecular patterns originating from invading microorganisms and initiate innate immune responses. Toll-like receptors 8 and 7 (TLR8 and TLR7) are endosomal immune receptors and take a key role in innate and adaptive immunity. As a transmembrane receptor, TLR8 could recognize single-stranded RNA. Activation of TLR8 and TLR7 lead to immune cell stimulation and inflammatory cytokine production, which is normally a protective host response.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
VTX-1463 VTX-1463 Phase 1 Clinical Ventirx Rhinitis, Allergic Details
CB-06 CB 06036; CB-06 Phase 1 Clinical Shanghai Zhimeng Biopharma Inc Hepatitis B Details
Telratolimod 3M-052; MEDI-9197 3m Healthcare Ltd Details
BDC-1001 BDC-1001 Bolt Biotherapeutics Details
Bazlitoran IMO-8400 Idera Details
HRS-9950 HRS-9950 Phase 1 Clinical Jiangsu Hengrui Medicine Co Ltd, Suzhou Suncadia Biopharmaceuticals Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd Hepatitis B, Chronic Details
DN-1508052 DN-1508052; DN1508052-01 Phase 2 Clinical Shanghai De Novo Pharmatech Co Ltd Solid tumours Details
CV-8102 CV-8102 Phase 1 Clinical Curevac Ag Squamous Cell Carcinoma of Head and Neck; Skin Neoplasms; Carcinoma, Adenoid Cystic; Rabies; Carcinoma, Squamous Cell; Carcinoma, Hepatocellular; Melanoma Details
TransCon-TLR-7/8-agonist Phase 2 Clinical Ascendis Pharma Oncology Division As Solid tumours Details
BDB-018 BDB-018 Phase 1 Clinical Seven And Eight Biopharmaceuticals Inc Solid tumours Details
Motolimod VTX-378; VTX-2337 Phase 1 Clinical Array Biopharma Lymphoma, B-Cell; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Ovarian Epithelial; Carcinoma, Verrucous; Salivary Gland Neoplasms; Peritoneal Neoplasms; Lymphoma; Fallopian Tube Neoplasms; Carcinoma, Squamous Cell; Laryngeal Neoplasms; Paranasal Sinus Neoplasms; Tongue Neoplasms Details
Selgantolimod GS-9688 Phase 2 Clinical Gilead Hepatitis B, Chronic Details
E-6742 E-6742 Phase 2 Clinical Eisai Co Ltd Lupus Erythematosus, Systemic Details
Enpatoran M-5049 Phase 2 Clinical Merck & Co Inc Lupus Erythematosus, Cutaneous; Coronavirus Disease 2019 (COVID-19); Lupus Erythematosus, Systemic Details
Afimetoran BMS-986256 Phase 2 Clinical Bristol-Myers Squibb Company Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic Details

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