Name:Toll like receptor 8 Target Synonym:UNQ249/PRO286,TLR8,Toll-like receptor 8,CD288,Toll Like Receptor 8,CD288 Antigen
Number of Launched Drugs:0 Number of Drugs in Clinical Trials:12 Lastest Research Phase:Phase 2 Clinical
TLR8/CD288/Toll-like receptor 8
Toll-like receptors (TLRs) sense pathogen-associated molecular patterns originating from invading microorganisms and initiate innate immune responses. Toll-like receptors 8 and 7 (TLR8 and TLR7) are endosomal immune receptors and take a key role in innate and adaptive immunity. As a transmembrane receptor, TLR8 could recognize single-stranded RNA. Activation of TLR8 and TLR7 lead to immune cell stimulation and inflammatory cytokine production, which is normally a protective host response.