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TLR8

Brief Information

Name:Toll like receptor 8
Target Synonym:UNQ249/PRO286,TLR8,Toll-like receptor 8,CD288,Toll Like Receptor 8,CD288 Antigen
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
TL8-H5253 Human Human TLR8 / CD288 Protein, Fc Tag
TL8-H5253-structure

Synonym Name

TLR8/CD288/Toll-like receptor 8

Background

Toll-like receptors (TLRs) sense pathogen-associated molecular patterns originating from invading microorganisms and initiate innate immune responses. Toll-like receptors 8 and 7 (TLR8 and TLR7) are endosomal immune receptors and take a key role in innate and adaptive immunity. As a transmembrane receptor, TLR8 could recognize single-stranded RNA. Activation of TLR8 and TLR7 lead to immune cell stimulation and inflammatory cytokine production, which is normally a protective host response.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Selgantolimod GS-9688 Phase 2 Clinical Gilead Hepatitis B, Chronic; Hepatitis B Details
Motolimod VTX-378; VTX-2337 Phase 2 Clinical Array Biopharma Lymphoma, B-Cell; Solid tumours; Ovarian Neoplasms; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Lymphoma; Fallopian Tube Neoplasms; Carcinoma, Squamous Cell Details
CV-9202 CV-9202; BI-1361849 Phase 2 Clinical Cancer Research Institute, Ludwig Institute For Cancer Research, Curevac Ag Carcinoma, Non-Small-Cell Lung Details
NKTR-262 NKTR-262 Phase 2 Clinical Nektar Therapeutics Ovarian Neoplasms; Carcinoma, Merkel Cell; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Urinary Bladder Neoplasms; Sarcoma; Breast Neoplasms; Colorectal Neoplasms; Melanoma Details
VTX-1463 VTX-1463 Phase 1 Clinical Ventirx Rhinitis, Allergic Details
CD-11301 R-848; S-28463; VML-600; CD-11301 Phase 2 Clinical 3m Keratosis, Actinic; Carcinoma, Basal Cell; Herpes Genitalis; Hepatitis B; Lymphoma, T-Cell, Cutaneous Details
SBT-6050 SBT-6050; SBT6050 Phase 1 Clinical Solid tumours Details
E-6742 E-6742 Phase 1 Clinical Eisai Co Ltd Neoplasms; Nervous System Diseases Details
DN-1508052 DN-1508052; DN1508052-01 Phase 1 Clinical Shanghai De Novo Pharmatech Co Ltd Solid tumours Details

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