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MAdCAM-1

Brief Information

Name:Mucosal addressin cell adhesion molecule-1
Target Synonym:Mucosal addressin cell adhesion molecule 1,MADCAM1,hMAdCAM-1,Mucosal Vascular Addressin Cell Adhesion Molecule 1,MACAM1,MAdCAM-1,Mucosal Addressin Cell Adhesion Molecule-1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
MAM-H5253 Human Human MAdCAM-1 Protein, Fc Tag (MALS verified)
MAM-H5253-structure
MAM-H5253-sds
MAM-H5253-elisa_1

Part of Bioactivity data

MAM-H5253-MALS-HPLC
Human MAdCAM-1, Fc Tag (Cat. No. ) MALS images

The purity of Human MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) was more than 90% and the molecular weight of this protein is around 145-175 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human MAdCAM-1, Fc TagHuman MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) ELISA bioactivity

Immobilized Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT7-H52W4) at 1 μg/mL (100 μL/well) can bind Human MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) with a linear range of 2-78 ng/mL (QC tested).

MAM-H5253-ELISA
Human MAdCAM-1, Fc TagHuman MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) ELISA bioactivity

Immobilized Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT7-H52W4) at 1 μg/mL (100 μL/well) can bind Human MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) with a linear range of 2-78 ng/mL (QC tested).

Synonym Name

MAdCAM-1,Mucosal vascular addressin cell adhesion molecule 1 transcript variant 1

Background

The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) takes a key role in the endothelial adhesion and migration of lymphocytes to sites of inflammation in inflammatory disease. In vitro and in vivo data indicate that blockade of the adhesion molecule mucosal address in cell adhesion molecule (MAdCAM) pathway decreases leukocyte homing to the gut by inhibiting the interaction between MAdCAM and its ligand the α4β7 integrin expressed on lymphocytes.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ontamalimab SHP-647; PF-547659; PF-00547659 Phase 3 Clinical Pfizer Inc Ileitis; Colitis, Ulcerative; Crohn Disease Details

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