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Brief Information

Name:Mucosal addressin cell adhesion molecule-1
Target Synonym:Mucosal addressin cell adhesion molecule 1,MADCAM1,hMAdCAM-1,Mucosal Vascular Addressin Cell Adhesion Molecule 1,MACAM1,MAdCAM-1,Mucosal Addressin Cell Adhesion Molecule-1
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

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Part of Bioactivity data


Human MAdCAM-1, His Tag (Cat. No. MAM-H52H4) immobilized on CM5 Chip can bind Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT7-H52W4) with an affinity constant of 0.227 μM as determined in a SPR assay (Biacore 8K) (QC tested).


Immobilized Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT7-H52W4) at 2 μg/mL (100 μL/well) can bind Human MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) with a linear range of 0.05-1 ng/mL (QC tested).

Synonym Name

MAdCAM-1,Mucosal vascular addressin cell adhesion molecule 1 transcript variant 1


The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) takes a key role in the endothelial adhesion and migration of lymphocytes to sites of inflammation in inflammatory disease. In vitro and in vivo data indicate that blockade of the adhesion molecule mucosal address in cell adhesion molecule (MAdCAM) pathway decreases leukocyte homing to the gut by inhibiting the interaction between MAdCAM and its ligand the α4β7 integrin expressed on lymphocytes.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Vedolizumab MLN-0002; LPD-02; MLN-002; MLN-02; LDP-02 Approved Millennium Pharmaceuticals Inc 安吉优, Entyvio United States Colitis, Ulcerative; Crohn Disease Takeda Pharmaceuticals U.S.A. Inc 2014-05-20 Colitis; Melanoma; Carcinoma, Non-Small-Cell Lung; Crohn Disease; Urogenital Neoplasms; Colitis, Ulcerative; Pediatric ulcerative colitis; Celiac Disease; Cholangitis, Sclerosing; Solid tumours; Neoplasms; Pouchitis; Pediatric Crohn's disease; Inflammatory Bowel Diseases; Acquired Immunodeficiency Syndrome; Hematopoietic stem cell transplantation (HSCT); HIV Infections Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ontamalimab SHP-647; PF-00547659; PF-547659 Phase 3 Clinical Pfizer Inc Ileitis; Colitis, Ulcerative; Crohn Disease Details
Vedolizumab biosimilar (Polpharma Biologics) PB-016 Phase 3 Clinical Polpharma Biologics Sa Pouchitis; Colitis, Ulcerative; Crohn Disease Details

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