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STEAP1

Brief Information

Name:Six-transmembrane epithelial antigen of the prostate 1
Target Synonym:PRSS24,Six-transmembrane epithelial antigen of prostate 1,STEAP,STEAP1,STEAP Family Member 1,Six Transmembrane Epithelial Antigen Of The Prostate 1,STEAP1 Metalloreductase,Six Transmembrane Epithelial Antigen Of The Prostate,Metalloreductase STEAP1,EC 1.1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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By Species:
By Tag:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
ST1-H52H3 Human Human STEAP1 Full Length Protein, His Tag (HEK293)
ST1-H52H3-structure
ST1-H52H3-sds

Synonym Name

STEAP1, PRSS24, STEAP

Background

Six-transmembrane epithelial antigen of the prostate 1 (STEAP1) is an integral membrane protein that is highly up-regulated on the cell surface of several human cancers, making it a promising therapeutic target to manage these diseases. It shares sequence homology with three enzymes (STEAP2-STEAP4) that catalyze the NADPH-dependent reduction of iron(III). Taking into account its high specificity and overexpression in human cancers, STEAP1 is nowadays a promising candidate to be imposed as a therapeutic target.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AMG-509 AMG-509 Phase 1 Clinical Amgen Inc Prostatic Neoplasms Details
89Zr-DFO-MSTP2109A Phase 2 Clinical Memorial Sloan Kettering Cancer Center, Genentech Inc Prostatic Neoplasms Details

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