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Your Position: Home > Integrin alpha-7 isoform X1 beta 1

Integrin alpha-7 isoform X1 beta 1

Synonym Name

integrin alpha-7 isoform X1 beta 1,ITGA7X1&ITGB1,ITGA7X1B1

Background

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.

Clinical and Translational Updates

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