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Your Position: Home > FGF-10

FGF-10

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Cat. No. Species Product Description Structure Purity Feature
FG0-H81Q7 Human Biotinylated Human FGF-10 / KGF 2 Protein, His,Avitag™ (SPR verified)
FG0-H81Q7-structure
FG0-H81Q7-sds
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Part of Bioactivity data

FG0-H81Q7-SPR
FGF-10 SPR

Biotinylated Human FGF-10, His,Avitag (Cat. No. FG0-H81Q7) immobilized on SA Chip can bind Human FGFR2 (IIIb), His Tag (Cat. No. FGB-H5223) with an affinity constant of 5.02 μM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol

Synonym Name

FGF-10,Fibroblast growth factor 10,Keratinocyte growth factor 2

Background

Fibroblast Growth Factor 10 (FGF 10) is an evolutionary conserved secreted growth factor mediating mostly mesenchymal to epithelial signaling. FGF 10 belongs to the FGF 7 subfamily and shares similar biochemical and amino acid sequences with its constituent members (FGF3, FGF 7 and FGF 22).  As a paracrine FGF, FGF 10 elicits its biological responses by activating the fibroblast growth factor receptor 2b (FGF R 2b), is crucial for governing proximal distal outgrowth as well as patterning and acts upstream of the known apical ectodermal ridge (AER) marker FGF 8. FGF10 is also implicated in pancreatic cancer, and that overexpression of FGFR2b is associated with metastatic invasion.

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