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Your Position: Home > IL-18

IL-18

Brief Information

Name:Interleukin 18
Target Synonym:Interferon gamma-inducing factor,IL-18,IFN-gamma-inducing factor,IGIF,Iboctadekin,IL18,Interleukin 18,Interleukin 18 (Interferon-Gamma-Inducing Factor),Interleukin-1 Gamma,IL-1 Gamma,IL1F4,Interferon-Gamma-Inducing Factor,Interleukin-18,IL-1g
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
IL8-H5113 Human Human IL-18 Protein, Tag Free (MALS verified)
IL8-H5113-structure
IL8-H5113-sds
ACRO Quality

Part of Bioactivity data

IL8-H5113-SPR
IL-18 SPR

Human IL-18BP, Fc Tag (Cat. No. ILP-H5253) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-18, Tag Free (Cat. No. IL8-H5113) with an affinity constant of 1.71 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
IL8-H5113-SPR
IL-18 SPR

Human IL-18 R1, Fc Tag (Cat. No. IL1-H5259) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human IL-18, Tag Free (Cat. No. IL8-H5113) with an affinity constant of 0.409 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

IL-18,Interleukin-18,IL18,IL-1 gamma,IGIF,IL1F4,IL-1F4

Background

Interleukin-18 (IL-18) is a potent proinflammatory cytokine that induces interferon-gamma (IFN-gamma) production from Th1 cells, NK cells and activated macrophages, particularly in the presence of IL-12. IL-18 also functions in developmental regulation of T-lymphocyte helper type I cells and in Fas-mediated cytotoxicity. Suppression of IL-18 activity is being investigated for treatment of chronic inflammatory diseases such as Crohn's disease and rheumatoid arthritis. It acts by inducing heterodimerization of the two subunits of its receptor, IL-18RAlpha and IL-18RBeta shows structural similarity to IL-1.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CMK-389 CMK-389; NOV-8 Novartis Pharma Ag Details
Tadekinig alfa (AB2 Bio) Phase 3 Clinical Ab2 Bio Ltd Macrophage Activation Syndrome; Cytokine Release Syndrome; Lymphohistiocytosis, Hemophagocytic Details
GSK-1070806 GSK-1070806 Phase 1 Clinical Glaxosmithkline Plc Rejection of renal transplantation; Inflammatory Bowel Diseases; Crohn Disease; Dermatitis, Atopic; Diabetes Mellitus Details
Camoteskimab AVTX-007; MEDI-2338; AEVI-007; CERC-007 Phase 1 Clinical Medimmune Llc Still's Disease, Adult-Onset; Multiple Myeloma; Pulmonary Disease, Chronic Obstructive Details

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