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Your Position: Home > CCL2

CCL2

Brief Information

Name:C-C motif chemokine 2
Target Synonym:MCP1,HC11,Monocyte chemotactic protein 1,Monocyte chemoattractant protein 1,CCL2,C-C Motif Chemokine Ligand 2,Monocyte Chemotactic And Activating Factor,Monocyte Secretory Protein JE,Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je),Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2,Monocyte Chemoattractant Protein-1,Chemokine (C-C Motif) Ligand 2,Small-Inducible Cytokine A2,SCYA2,MCP-1,MCAF,Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je,C
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CEA-B036 Human ClinMax™ Human MCP-1 / CCL2 ELISA Kit
CC2-H5255 Human Human CCL2 / MCP-1 Protein, Fc Tag (MALS verified)
CC2-H5255-structure
CC2-H5255-sds
ACRO Quality

Part of Bioactivity data

CC2-H5255-MALS-HPLC
Human CCL2, Fc Tag (Cat. No. ) MALS images

The purity of Human CCL2, Fc Tag (Cat. No. CC2-H5255) is more than 95% and the molecular weight of this protein is around 68-88 kDa verified by SEC-MALS.

Report
  • Background
    Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. CCL2, a member of the CC subfamily, is characterized by two adjacent cysteine residues. CCL2 displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
  • Clinical and Translational Updates
      

  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Synonym Name

CCL2/C-C motif chemokine 2/MCP-1/MCAF

Background

Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. CCL2, a member of the CC subfamily, is characterized by two adjacent cysteine residues. CCL2 displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AFX-5931 AFX-5931 Phase 2 Clinical Afecta Pharmaceuticals Inc Eczema Details
MW-151 MW01-9-034WH; MW-151; MW01-2-151SRM Phase 1 Clinical University Of Kentucky Drug-Related Side Effects and Adverse Reactions; Poisoning; Cognition Disorders Details
64CU-DOTA-ECL1i Phase 1 Clinical Washington University School Of Medicine Carotid Artery Diseases; Heart Diseases; Arteriosclerosis Details

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