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CD98

Brief Information

Name:L-type amino acid transporter 1
Target Synonym:MPE16,Integral Membrane Protein E16,CD98 Light Chain,Large Neutral Amino Acids Transporter Small Subunit 1,Solute Carrier Family 7 Member 5,4F2 LC,Large Neutral Amino Acid-Transporter 1,SLC7A5,LAT1,Solute Carrier Family 7 (Cationic Amino Acid Transporter,
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CD8-HF248 Human FITC-Labeled Human CD98 Protein, His Tag
CD8-HF248-structure
CD8-H5247 Human Human CD98 Protein, His Tag (MALS verified)
CD8-H5247-structure
CD8-H5247-sds

Part of Bioactivity data

CD8-H5247-MALS-HPLC
Human CD98, His Tag (Cat. No. ) MALS images

The purity of Human CD98, His Tag (Cat. No. CD8-H5247) was more than 90% and the molecular weight of this protein is around 50-70 kDa verified by SEC-MALS.

  • Background
    CD antigen CD98 is also known as 4F2 cell-surface antigen heavy chain (4F2hc), 4F2 heavy chain antigen, Solute carrier family 3 member 2 (SLC3A2), Lymphocyte activation antigen 4F2 large subunit, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family.. SLC3A2 / CD98 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. SLC3A2 / CD98 is required for the function of light chain amino-acid transporters and also involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. CD98 involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A5 or SLC7A8, CD98 involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Synonym Name

SLC3A2,CD98,4F2,4F2HC,4T2HC,CD98HC,MDU1,NACAE

Background

CD antigen CD98 is also known as 4F2 cell-surface antigen heavy chain (4F2hc), 4F2 heavy chain antigen, Solute carrier family 3 member 2 (SLC3A2), Lymphocyte activation antigen 4F2 large subunit, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family.. SLC3A2 / CD98 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. SLC3A2 / CD98 is required for the function of light chain amino-acid transporters and also involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. CD98 involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A5 or SLC7A8, CD98 involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
JPH-203 JPH-203; KYT-0353; JPH-203SBECD Phase 2 Clinical J-Pharma Biliary Tract Neoplasms Details
[18F]AA-7 [18F]AA-7 Clinical Osaka City University, Institute Physical Chemical Research (Riken), Nagase Medicals Glioma Details
TX-101 TX-101; [124I]IPA; 124I-ACD-101; [124I]ACD-101 Phase 2 Clinical Telix Pharmaceuticals Diagnostic agents Details
R-OKY-034F R-OKY-034F Phase 2 Clinical Osaka University, Japan Agency For Medical Research And Development Pancreatic Neoplasms Details
QBS-10072S QBS-10072S Phase 1 Clinical Novotech (Australia) Pty Ltd Sarcoma; Uterine Cervical Neoplasms; Tongue Neoplasms; Melanoma; Neoplasm Metastasis; Lung Neoplasms; Brain metastases; Thymoma; Central Nervous System Diseases; Urologic Neoplasms; Colorectal Neoplasms; Astrocytoma; Prostatic Neoplasms; Liver Neoplasms; Brain Neoplasms; Breast Neoplasms; Cholangiocarcinoma; Urinary Bladder Neoplasms; Mesothelioma; Pancreatic Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Kidney Neoplasms; Head and Neck Neoplasms; Ovarian Neoplasms Details
NBQ72S NBQ72S Phase 1 Clinical Brain Neoplasms Details

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