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Your Position: Home > Cadherin-17


Brief Information

Target Synonym:Liver-intestine cadherin,HPT-1,Intestinal peptide-associated transporter HPT-1,LI-cadherin,HPT-1 Cadherin,Cadherin 17, LI Cadherin (Liver-Intestine),HPT1,Human Intestinal Peptide-Associated Transporter HPT-1,LI Cadherin,Cadherin,Cadherin 17,Human Peptide Transporter 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 2 Clinical

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
CDH17 mAb - 03 PCC Solid Tumor Colorectal cancer,Gastric Cancer

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Part of Bioactivity data

 Cadherin-17 SPR

Anti-Cadherin-17 antibody captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human Cadherin-17, His Tag (Cat. No. CA7-H52H3) with an affinity constant of 2.9 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

 Cadherin-17 SPR

Anti-CDH17-antibody captured on Protein A Chip can bind Cynomolgus Cadherin-17, His Tag (Cat. No. CA7-C52H4) with an affinity constant of 41.8 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name



Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CHM-2101 CDH17-CAR T; CHM-2101; CHM2101; CHM-2101 CAR-T cells Phase 2 Clinical University Of Pennsylvania Stomach Neoplasms; Pancreatic Neoplasms; Neuroendocrine Tumors; Colorectal Neoplasms; Gastrointestinal Neoplasms Details
BI-905711 BI-905711 Phase 1 Clinical Boehringer Ingelheim Gmbh Pancreatic Neoplasms; Cholangiocarcinoma; Gastrointestinal Neoplasms Details
ARB-202 ARB-202 Phase 1 Clinical Arbele Corp Liver Neoplasms; Biliary Tract Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Esophageal adenocarcinoma; Gastrointestinal Neoplasms Details

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