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Your Position: Home > CXCL13

CXCL13

Brief Information

Name:C-X-C motif chemokine 13
Target Synonym:BCA-1,B cell-attracting chemokine 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Cat. No. Species Product Description Structure Purity Feature
CX3-H1249 Human Human CXCL13 / BCA-1 Protein, His Tag
CX3-H1249-structure

Synonym Name

C-X-C motif chemokine 13,Angie,B cell-attracting chemokine 1,BCA-1,B lymphocyte chemoattractant,CXC chemokine BLC,Small-inducible cytokine B13,CXCL13,BCA1,BLC,SCYB13

Background

CXCL13, originally known as BLC (B-lymphocyte chemoattractant) or BCA-1 (B cell-attracting chemokine 1), is a homeostatic chemokine. It is constitutively secreted by stromal cells in B-cell areas of secondary lymphoid tissues (follicles), such as spleen, lymph nodes, tonsils, and Peyer's patches. CXCL13 plays a key role in orchestrating cell migration within spatially distinct regions of the secondary lymphoid organs. It strongly attracts B lymphocytes while promoting migration of only small numbers of T cells and macrophages. CXCL13 exerts its functions through its receptor CXCR5, which initially, was isolated from Burkitt Lymphoma and therefore designated as Burkitt's lymphoma receptor 1 (BLR1).

Clinical and Translational Updates

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