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CD131

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Cat. No. Species Product Description Structure Purity Feature
CD1-H5256 Human Human IL-3 R Beta / CD131 Protein, Fc Tag (MALS verified)
CD1-H5256-structure
CD1-H5256-sds
ACRO Quality

Part of Bioactivity data

CD1-H5256-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human CD131, Fc Tag (Cat. No. CD1-H5256) on Protein A Biosensor, can bind Human GM-CSF, premium grade (Cat. No. GMF-H4214) with an affinity constant of 7.4 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol
CD1-H5256-MALS-HPLC
Human CD131, Fc Tag (Cat. No. ) MALS images

The purity of Human CD131, Fc Tag (Cat. No. CD1-H5256) is more than 85% and the molecular weight of this protein is around 150-175 kDa verified by SEC-MALS.

Report
Bioactivity-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human CD131, Fc Tag (Cat. No. CD1-H5256) on Protein A Biosensor, can bind Human GM-CSF, premium grade (Cat. No. GMF-H4214) with an affinity constant of 7.4 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

IL-3 R Beta,CD131,Common beta Chain

Background

CD131- the common β Subunit, is a member of the type 1 cytokinereceptor family. There are three major classes of heteroreceptor complexes, where the receptor complex utilises a common shared receptor subunit as a signal-transducing chain along with a cytokine specific subunit. These three classes include those which use gp130, those which use γc and those which use the common β subunit, βc(CD131). CD131 is shared by three of the “four-helical bundle” family of cytokines; IL-3, IL-5 and GM-CSF, and forms a receptor complex along with a cytokine specific α chain for each of these cytokines.Moreover, even though each of these cytokines have their own specific α subunit, the co-utilisation of CD131 suggests a common intra-cellular process of both unique and/or overlapping activities on expressing cells.

Clinical and Translational Updates

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