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Your Position: Home > IL-17B


Brief Information

Name:Interleukin-17 receptor B
Target Synonym:IL-17 receptor B,IL-17RB,Cytokine receptor-like 4,IL-17 receptor homolog 1,IL-17Rh1,IL17Rh1,Interleukin-17B receptor,IL-17B receptor
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Part of Bioactivity data


Immobilized Biotinylated Human IL-17B, Fc,Avitag (Cat. No. ILB-H82F1) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-Human IL17B Monoclonal Antibody with a linear range of 0.1-8 ng/mL (Routinely tested).

IL-17B MALS images

The purity of Biotinylated Mouse IL-17B Protein, Fc,Avitag (Cat. No. ILB-M82F3) is more than 85% and the molecular weight of this protein is around 100-120 kDa verified by SEC-MALS.

Synonym Name

Interleukin-17B,Cytokine Zcyto7,Interleukin-20,IL-20,Neuronal interleukin-17-related factor,IL17B,IL20, NIRF, ZCYTO7


IL-17B is a member of IL17 famaily,  was originally described as a proinflammatory cytokine. IL-17B is produced by neutrophils and potentiates TNF-α effect on the production of cytokines and chemokines, such as IL-6, G-CSF, and CCL20, known to control immune cell trafficking to inflamed tissues. Interestingly, although IL-17B and IL-17E (IL-25) share a common receptor, IL-17RB, IL-17B, and IL-17E deficiency lead to opposite results in a model of acute colitis induced by dextran sulfate sodium. IL-17B inhibits IL-17E binding to IL-17RA– IL-17RB complexes on epithelial cells, and limits IL-17E-induced IL-6 production by colon epithelial cells.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SM-17 SM-17; SM17 Phase 1 Clinical Sinomab Bioscience Ltd Idiopathic Pulmonary Fibrosis; Asthma; Dermatitis, Atopic Details

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