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Your Position: Home > IL-17B

IL-17B

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Cat. No. Species Product Description Structure Purity Feature
ILB-H5257 Human Human IL-17B Protein, Fc Tag
ILB-H5257-structure
ILB-H5249 Human Human IL-17B Protein, His Tag
ILB-H5249-structure

Synonym Name

Interleukin-17B,Cytokine Zcyto7,Interleukin-20,IL-20,Neuronal interleukin-17-related factor,IL17B,IL20, NIRF, ZCYTO7

Background

IL-17B is a member of IL17 famaily,  was originally described as a proinflammatory cytokine. IL-17B is produced by neutrophils and potentiates TNF-α effect on the production of cytokines and chemokines, such as IL-6, G-CSF, and CCL20, known to control immune cell trafficking to inflamed tissues. Interestingly, although IL-17B and IL-17E (IL-25) share a common receptor, IL-17RB, IL-17B, and IL-17E deficiency lead to opposite results in a model of acute colitis induced by dextran sulfate sodium. IL-17B inhibits IL-17E binding to IL-17RA– IL-17RB complexes on epithelial cells, and limits IL-17E-induced IL-6 production by colon epithelial cells.

Clinical and Translational Updates

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