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Your Position: Home > CD43

CD43

Brief Information

Name:Leukosialin
Target Synonym:GPL115,GALGP,Galactoglycoprotein,Leukocyte sialoglycoprotein,Sialophorin,CD43
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Cat. No. Species Product Description Structure Purity Feature
CD3-H52H9 Human Human CD43 / leukosialin Protein, His Tag (MALS & SPR verified)
CD3-H52H9-structure
CD3-H52H9-sds
ACRO Quality

Part of Bioactivity data

CD3-H52H9-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human Siglec-1, His Tag (Cat. No. SG1-H52H3) immobilized on CM5 Chip can bind Human CD43, His Tag (Cat. No. CD3-H52H9) with an affinity constant of 76.1 μM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
CD3-H52H9-MALS-HPLC
Human CD43, His Tag (Cat. No. ) MALS images

The purity of Human CD43, His Tag(Cat. No. CD3-H52H9) is more than 90% and the molecular weight of this protein is around 38-48 kDa verified by SEC-MALS.

Report
Bioactivity-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human Siglec-1, His Tag (Cat. No. SG1-H52H3) immobilized on CM5 Chip can bind Human CD43, His Tag (Cat. No. CD3-H52H9) with an affinity constant of 76.1 μM as determined in a SPR assay (Biacore 8K) (QC tested).

Synonym Name

leukosialin, sialophorin, GPL115, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein

Background

CD43 or leukosialin or sialophorin, is predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. In hematopathology, CD43 is often considered as a T-cell associated marker, because it is expressed by over 95% of thymocytes and peripheral blood T cells. CD43 positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN).

Clinical and Translational Updates

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